Survival Significance of Molecular Pathology and Genetic Variation in Brain Gliomas

NCT ID: NCT04216537

Last Updated: 2021-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2025-06-01

Brief Summary

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This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology and genetic data. This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

Detailed Description

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Precise classification based on molecular and genetic biomarkers/subgroups for gliomas is challenging. This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology (1p/19q co-deletion, MGMT methylation, IDH and TERTp mutations, etc) and genetic data (Whole exome sequencing, RNA sequencing, proteomics, etc). This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

Conditions

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Glioma Molecular Sequence Variation Genetic Change

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Interventions

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Glioma groups based on molecular pathology or genetic variation

Patients with newly diagnosed glioma that receive tumor resection

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients must have radiologically and histologically confirmed diagnosis of primary glioma
* Life expectancy of greater than 3 months
* Must receive tumor resection
* Must have sufficient fresh frozen tissues for NGS
* Signed informed consent

Exclusion Criteria

* No gliomas
* No sufficient amount of tumor tissues for detection of molecular pathology
* Patients who are pregnant or breast feeding
* Patients who are suffered from severe systematic malfunctions
* Do not have sufficient fresh frozen tissues for NGS
Minimum Eligible Age

1 Year

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The First Affiliated Hospital of Zhengzhou University

OTHER

Sponsor Role lead

Responsible Party

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Zhenyu Zhang

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Neurosurgery, First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zhenyu Zhang, Dr.

Role: CONTACT

+86 17839973727

Facility Contacts

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Zhenyu Zhang, Dr.

Role: primary

+86 17839973727

Other Identifiers

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GiomaMG-1

Identifier Type: -

Identifier Source: org_study_id

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