Prognostic Impact of Surgical Resection Extent for Supratentorial High Grade Gliomas.
NCT ID: NCT03997136
Last Updated: 2019-08-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
28 participants
OBSERVATIONAL
2019-09-01
2021-07-01
Brief Summary
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Detailed Description
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Investigators will compare the outcomes/survival rate and clinical outcome of the different resection types (Total, near total, subtotal/debulking) of supratentorial high grade gliomas according to the clinical condition and comorbidities of the patient, the location and morphology of the lesion, the grading of lesions, and the clinical experience of the neurosurgeon.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Supratentorial high grade gliomas resection.
Total, near total or subtotal/debulking resection of the brain supratentorial high grade gliomas
Eligibility Criteria
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Inclusion Criteria
* Denovo disease for the first time.
* Any age
Exclusion Criteria
* Infratentorial high-grade gliomas.
* Past history of gliomas.
* Patients who are unfit for any neurosurgical interventions.
* Patients who do not receive their adjuvant standard therapy.
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Amr Badary
Resident Doctor
Principal Investigators
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Mahmoud Ragab
Role: STUDY_DIRECTOR
Assiut University
Central Contacts
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References
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Gulati S, Jakola AS, Nerland US, Weber C, Solheim O. The risk of getting worse: surgically acquired deficits, perioperative complications, and functional outcomes after primary resection of glioblastoma. World Neurosurg. 2011 Dec;76(6):572-9. doi: 10.1016/j.wneu.2011.06.014.
Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS. The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol. 2014 Jul;16(7):896-913. doi: 10.1093/neuonc/nou087.
Ryken TC, Frankel B, Julien T, Olson JJ. Surgical management of newly diagnosed glioblastoma in adults: role of cytoreductive surgery. J Neurooncol. 2008 Sep;89(3):271-86. doi: 10.1007/s11060-008-9614-5. Epub 2008 Aug 20. No abstract available.
Sanai N, Polley MY, McDermott MW, Parsa AT, Berger MS. An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg. 2011 Jul;115(1):3-8. doi: 10.3171/2011.2.jns10998. Epub 2011 Mar 18.
Orringer D, Lau D, Khatri S, Zamora-Berridi GJ, Zhang K, Wu C, Chaudhary N, Sagher O. Extent of resection in patients with glioblastoma: limiting factors, perception of resectability, and effect on survival. J Neurosurg. 2012 Nov;117(5):851-9. doi: 10.3171/2012.8.JNS12234. Epub 2012 Sep 14.
Other Identifiers
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Brain Gliomas Surgery
Identifier Type: -
Identifier Source: org_study_id
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