Assessment of the Efficacy of Microosteoperforations Versus Injectable Platelet-rich Fibrin During Orthodontic Leveling and Alignment of Mandibular Incisors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-01

Study Completion Date

2024-12-01

Brief Summary

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The aim of this prospective clinical study will be to compare the efficacy of micro osteoperforations versus injectable platelet-rich fibrin during orthodontic leveling and alignment of mandibular incisors.

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Detailed Description

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Conditions

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Effect of Platelet Rich Fibrin Versus Microosteoperforation Compaed to Control Group Toothmovement

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Microosteoperforation

MOPs with leveling and alignment that will be performed tow time according to standardized protocol

Group Type EXPERIMENTAL

MOPs with leveling and alignment

Intervention Type PROCEDURE

mop

Injectable platelet rich fibrin

i-PRF with leveling and alignment that will be performed tow time according to standardized protocol

Group Type EXPERIMENTAL

iprf

Intervention Type BIOLOGICAL

i-PRF with leveling and alignment

control group

leveling and alignment that will be performed without any intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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iprf

i-PRF with leveling and alignment

Intervention Type BIOLOGICAL

MOPs with leveling and alignment

mop

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. An age range from 15 to 25 years.
2. Participants who had a full set of permanent dentitions excluding the third molar.
3. Participants who had moderate crowding in the mandibular arch according to Little's irregularity index that necessitates non-extraction treatment in the mandibular arch.
4. Normal vertical facial proportions.
5. Participants who had good oral hygiene and no periodontal disease.
6. No systemic diseases or regular medication that could interfere and/or affect orthodontic teeth movement.
7. No evidence of craniofacial anomalies, such as clef lip and palate or previous history of trauma, bruxism, or parafunction.
8. No tooth size, shape, or root abnormalities visible on patient's radiographic records.

Exclusion Criteria

1. Previous orthodontic treatment.
2. Any skeletal dysplasia or craniofacial malformation.
3. Retained primary or missing permanent teeth in the anterior area, and any kind of tooth/root shape anomaly or history of trauma affecting the incisors.
4. Systemic diseases or regular use of medications that could interfere with OTM.
5. Patients with root resorption, impacted canines, or dental anomalies.
6. Poor oral hygiene and uncontrolled periodontal diseases.

Minimum Eligible Age

15 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes