Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2021-06-15

Brief Summary

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Several methods aiming at the acceleration of orthodontic tooth movement have been proposed, including low-level laser therapy (LLLT), which showed promising results. However, the frequency of patient recall has been one of its major drawbacks.

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Detailed Description

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A randomized controlled clinical trial will be conducted to address the aim of the study. Sixteen patients will be recruited, requiring the therapeutic extraction of the maxillary 1st premolars, with subsequent canine retraction into the extraction space. The sample will be randomly divided into 2 equal groups, each including 8 subjects.

In Group A, one side of the maxillary arch will randomly receive LLLT on days 0, 3, 7, 14, and every 2 weeks thereafter, while in Group B, one side will also be randomly chosen to receive LLLT every 3 weeks. The contralateral sides of both groups will serve as the controls. The LLLT applied will be Diode laser emitting infrared radiation at wavelength of 980 nm, in a continuous mode.

Canine retraction in both groups will be carried out bilaterally using nickel-titanium closed-coil spring, delivering 150 grams of force, and the rate of tooth movement will be checked every 3 weeks, over a period of 3 months. Other variables will be also examined including, interleukin-1β level in the gingival crevicular fluid, root resorption, and molar anchorage loss.

Conditions

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Malocclusion

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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low-level laser therapy applied on days 0, 3,7,14 & every 2 weeks

Group Type EXPERIMENTAL

low-level laser therapy applied on days 0, 3,7,14 & every 2 weeks

Intervention Type OTHER

one side of the maxillary arch will randomly receive LLLT on days 0, 3, 7, 14, and every 2 weeks thereafter and the contralateral side will serve as the controls.

low-level laser therapy applied every 3 weeks

Group Type ACTIVE_COMPARATOR

low-level laser therapy applied every 3 weeks

Intervention Type OTHER

one side will also be randomly chosen to receive LLLT every 3 weeks and the contralateral side will serve as the controls.

Interventions

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low-level laser therapy applied on days 0, 3,7,14 & every 2 weeks

one side of the maxillary arch will randomly receive LLLT on days 0, 3, 7, 14, and every 2 weeks thereafter and the contralateral side will serve as the controls.

Intervention Type OTHER

low-level laser therapy applied every 3 weeks

one side will also be randomly chosen to receive LLLT every 3 weeks and the contralateral side will serve as the controls.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Malocclusion requires at least the extraction of maxillary first premolars, followed by canine retraction into the extraction site.
* Normal shape and structure of the maxillary canines, with no history of root canal treatment.
* Patients with good oral hygiene, and a healthy periodontal condition.

Exclusion Criteria

* Patients who underwent previous orthodontic treatment.
* Patients currently receiving drug therapy that may affect orthodontic tooth movement, e.g. hormonal therapy and corticosteroids.
* Patients with chronic diseases that may affect the rate of tooth movement.
* Pregnancy and lactation

Minimum Eligible Age

15 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No