Low Level Laser Therapy Applied in Orthodontic Tooth Movement

NCT ID: NCT05695053

Last Updated: 2025-02-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-27

Study Completion Date

2023-08-26

Brief Summary

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Currently, orthodontic treatment takes 2-3 years.. If we accelerate tooth movement by low energy laser therapy, we could reduce treatment time. Low Level Laser Therapy(LLLT) applied in Orthodontic Tooth Movement, which stimulates formation of osteoclast-like cells expression in vitro. Osteoclast can be served as an index for tooth movement. Increasing the number of osteoclast will increase bone formation and tooth movement. We plan to find a useful clinical protocol to improve the efficiency of orthodontic tooth movement. Test low energy laser in vitro. Find an effective wavelength and irradiation time to stimulate formation of osteoclast. Develop an useful protocol that clinical orthodontist could follow and reduce orthodontic treatment time.

Detailed Description

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Conditions

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Orthodontic Appliance Complication

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DEVICE_FEASIBILITY

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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with LLLT

Group Type EXPERIMENTAL

Low Level Laser Therapy

Intervention Type DEVICE

Low level laser therapy could provide energy to trigger cell differentiation.

without LLLT

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Placebo

Interventions

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Low Level Laser Therapy

Low level laser therapy could provide energy to trigger cell differentiation.

Intervention Type DEVICE

Placebo

Placebo

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with good oral hygiene
* 18 years old
* Patients who required bilateral canine retraction into the extracted premolar

Exclusion Criteria

* Serious medical history
* Poor oral hygiene
* Previous orthodontic treatment
* Orthognathic surgery or syndromic patients
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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China Medical University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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SHENG-FEN HUANG

Role: STUDY_CHAIR

China Medical University Hospital

Locations

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China Medical University Hospital

Taichung, , Taiwan

Site Status

Countries

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Taiwan

References

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Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci. 2014 Spring;5(2):58-62.

Reference Type RESULT
PMID: 25653800 (View on PubMed)

Other Identifiers

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CMUH110-REC2-138

Identifier Type: -

Identifier Source: org_study_id

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