Impact of Injectable Platelet Rich Fibrin Versus Low-intensity Pulsed Ultrasound on Different Orthodontic Tooth Movements During Clear Aligner Therapy
NCT ID: NCT06276985
Last Updated: 2024-02-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
82 participants
INTERVENTIONAL
2024-02-25
2024-07-25
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
NONE
Study Groups
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Experimental: Lipus side: closure of premolar extraction space
application of LIPUS with translation of closure of premolar extraction space that will be performed on intervention sides according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
No Intervention: LIPUS side control side
LIPUS side:closure of premolar extraction space control side
No interventions assigned to this group
Experimental:iPRF side closure of premolar extraction space
closure ofpremolar extraction space that will be performed with iPRFapplication according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
iPRF side closure of premolar extraction spacecontrol side
iPRF side canine retraction control side wihout intervention
No interventions assigned to this group
Experimental: LIPUS groupMolar distalization group inrervention side
distalization assisted with LIPUS according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
No Intervention: LIPUS groupMolar distalization group control side
distalization without LIPUS intervention
No interventions assigned to this group
Experimental: iPRFgroup: distalization intervntion side
distalization will be commenced with application of iPRF according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
No Intervention: iPRF group: distalization control side
distalization will be commenced without application of LLLT according to a standardized protocol
No interventions assigned to this group
Experimental: LIPUS group: leveling and alignment
leveling and alignment assisted with LIPUS according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
Experimental: iPRF group: leveling and alignment
leveling and alignment be commenced with application of iPRF according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
No Intervention: leveling and alignment without intervention
leveling and alignment without intervention
No interventions assigned to this group
Experimental: LIPUS group: Intrusion
intrusion assisted with LIPUS according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
Experimental: iPRF group: Intrusion
intrusion assisted with application of iPRF according to a standardized protocol
low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
No Intervention: intrusion control group
intrusion without intervention
No interventions assigned to this group
Interventions
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low intensity pulsed ultrasound and iPRF
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
1\. Age ranges from 14 to 17 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement
initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria
Age, 15 to 25 years; Class ii division 1 malocclusion with mild or no crowding; No previous orthodontic treatment; No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency; Adequate oral hygiene; Probing depth values not exceeding 3 mm across the Entire dentition; Adequate thickness of the attached gingiva (1-2 mm); No radiographic evidence of bone loss -
Exclusion Criteria
15 Years
22 Years
ALL
Yes
Sponsors
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Al-Azhar University
OTHER
Responsible Party
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farouk ahmed hussein
prinicpaI Investigator
Locations
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AlAzhar university
Cairo, , Egypt
Countries
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Other Identifiers
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977/91
Identifier Type: -
Identifier Source: org_study_id
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