Consequence of Injectable Platelets Rich Fibrin Versus Microosteopeforation on Root Resorption During Orthodontic Intrusion of Incisor Teeth

NCT ID: NCT05958498

Last Updated: 2023-07-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-31

Study Completion Date

2024-08-31

Brief Summary

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Consequence of injectable platelets rich fibrin versus microosteopeforation on root resorption during orthodontic intrusion of incisor teeth

Detailed Description

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Consequence of injectable platelets rich fibrin versus microosteopeforation on root resorption during orthodontic intrusion of incisor teeth: A comparative clinical study

Conditions

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Compare the Effect of Injectable Platelets Rich Fibrin and Micro-osteoperforations on Root Resorption During Orthodontic Intrusion of Incisors

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Group I

who will receive intrusive arches after leveling and alignment assisted with i-PRF according to standardized protocol

Group Type ACTIVE_COMPARATOR

injectable platelet rich fibrin and microosteoperforation

Intervention Type COMBINATION_PRODUCT

i-PRF which second product of blood versus mops which is surgical procedure

Group II

Will includes 9 patients who will receive intrusive utility arches after leveling and alignment assisted with (MOPs) according to standardized protocol.

Group Type ACTIVE_COMPARATOR

injectable platelet rich fibrin and microosteoperforation

Intervention Type COMBINATION_PRODUCT

i-PRF which second product of blood versus mops which is surgical procedure

Interventions

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injectable platelet rich fibrin and microosteoperforation

i-PRF which second product of blood versus mops which is surgical procedure

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* 1\. Patients with age range between 12-16 years. 2. Overbite \> 40% indicated for maxillary intrusion. 3. Mild to moderate crowding of upper incisors. 4. All permanent teeth erupted (excluding 3rd molars). 5. No previous orthodontic treatment. 6. Good oral hygiene with no previous periodontal surgery.

Exclusion Criteria

1. \- Transverse and/or vertical skeletal dysplasia or craniofacial malformation. 2. Retained primary or missing permanent teeth in the maxillary anterior area, and any kind of tooth/root shape anomaly.

3\. Patients with root resorption, impacted canines, or dental anomalies. 4. Poor oral hygiene 5. Present or history of periodontal diseases. 6. Systemic diseases or regular use of medications that could interfere with orthodontic tooth movement.

7\. History of trauma affecting the maxillary incisors. 8. Endodontically treated upper anterior teeth.
Minimum Eligible Age

15 Years

Maximum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Al-Azhar University

OTHER

Sponsor Role lead

Responsible Party

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farouk ahmed hussein

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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AlAzhar university

Cairo, , Egypt

Site Status

Countries

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Egypt

References

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Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021 Mar 2;21(1):92. doi: 10.1186/s12903-021-01456-9.

Reference Type BACKGROUND
PMID: 33653326 (View on PubMed)

Dos Santos CCO, Mecenas P, de Castro Aragon MLS, Normando D. Effects of micro-osteoperforations performed with Propel system on tooth movement, pain/quality of life, anchorage loss, and root resorption: a systematic review and meta-analysis. Prog Orthod. 2020 Jul 27;21(1):27. doi: 10.1186/s40510-020-00326-4.

Reference Type BACKGROUND
PMID: 32715352 (View on PubMed)

Other Identifiers

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922/91

Identifier Type: -

Identifier Source: org_study_id

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