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The Influence of Menopausal Status on Myocardial Stiffness and Exercise Capacity Among Female Masters Endurance Athletes.

NCT ID: NCT06475768

Last Updated: 2025-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-14

Study Completion Date

2025-10-06

Brief Summary

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The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.

Detailed Description

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Conditions

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Myocardial Stiffness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Premenopausal Female Athletes

Stress Echocardiogram

Intervention Type DIAGNOSTIC_TEST

Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography.

Cardiovascular Magnetic Imaging (cMRI)

Intervention Type DIAGNOSTIC_TEST

Non-invasive imaging scan used to examine function and structure of the heart

Cardiac Magnetic Resonance Elastography (cMRE)

Intervention Type DIAGNOSTIC_TEST

Non-invasive imaging scan used to measure myocardial stiffness

Postmenopausal Female Athletes

Stress Echocardiogram

Intervention Type DIAGNOSTIC_TEST

Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography.

Cardiovascular Magnetic Imaging (cMRI)

Intervention Type DIAGNOSTIC_TEST

Non-invasive imaging scan used to examine function and structure of the heart

Cardiac Magnetic Resonance Elastography (cMRE)

Intervention Type DIAGNOSTIC_TEST

Non-invasive imaging scan used to measure myocardial stiffness

Male Athletes

Stress Echocardiogram

Intervention Type DIAGNOSTIC_TEST

Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography.

Cardiovascular Magnetic Imaging (cMRI)

Intervention Type DIAGNOSTIC_TEST

Non-invasive imaging scan used to examine function and structure of the heart

Cardiac Magnetic Resonance Elastography (cMRE)

Intervention Type DIAGNOSTIC_TEST

Non-invasive imaging scan used to measure myocardial stiffness

Interventions

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Stress Echocardiogram

Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography.

Intervention Type DIAGNOSTIC_TEST

Cardiovascular Magnetic Imaging (cMRI)

Non-invasive imaging scan used to examine function and structure of the heart

Intervention Type DIAGNOSTIC_TEST

Cardiac Magnetic Resonance Elastography (cMRE)

Non-invasive imaging scan used to measure myocardial stiffness

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Longstanding history of competitive endurance athletic performance defined as \>15 years of continuous athletic training for at least 7 hours per week and ongoing engagement in competitive events.

Exclusion Criteria

* A current or prior diagnosis of cardiovascular disease as defined by the presence of structural heart disease, heart failure, symptomatic coronary artery disease, more than moderate valve disease or prior valve surgery,
* Current or recent pregnancy within 1 year
* Positive pregnancy test (study visit 1)
* Concurrent or use within 1 year of oral contraceptives or hormone replacement therapy,
* Unable to undergo a cMRI (Please refer standard clinical contraindications for MRI)
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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Kathryn F. Larson

Senior Associate Consultant, Cardiovascular Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kathryn Larson, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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Mayo Clinic

Rochester, Minnesota, United States

Site Status

Countries

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United States

Other Identifiers

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24-001460

Identifier Type: -

Identifier Source: org_study_id