Coronary Artery Disease (CAD) in Women Marathon Runners
NCT ID: NCT00918372
Last Updated: 2010-09-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
50 participants
OBSERVATIONAL
2009-05-31
2010-06-30
Brief Summary
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Detailed Description
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The study will determine whether moderate to high intensity, long term athletic training and competition is associated with enhanced coronary artery disease in women. Each participant will complete a life-style, training volume and risk factor questionnaire. These participants will be compared to an age, gender and risk factor matched cohort.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Extreme fitness
Female competitive long distance runners
No interventions assigned to this group
Control
Age and Risk matched controls
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age \> 40 years old
* Agree to participate and sign an informed consent form
Exclusion Criteria
* Creatinine ≥ 2.0
* Pregnant Female
* Has run a marathon within the past 2 weeks
40 Years
FEMALE
Yes
Sponsors
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Boston Scientific Corporation
INDUSTRY
Minneapolis Heart Institute Foundation
OTHER
Responsible Party
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Minneapolis Heart Institute Foundation
Principal Investigators
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Robert S Schwartz, MD
Role: PRINCIPAL_INVESTIGATOR
Minneapolis Heart Institute Foundation
Locations
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Minneapolis Heart Institute at Abbott Northwestern Hospital
Minneapolis, Minnesota, United States
Countries
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References
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Angeli SJ, Haft JI. Severe coronary artery disease in a marathon runner. Chest. 1987 Feb;91(2):271-2. doi: 10.1378/chest.91.2.271.
Bassler TJ. Coronary-artery disease in marathon runners. N Engl J Med. 1980 Jan 3;302(1):57-8. No abstract available.
Colt E. Coronary-artery disease in marathon runners. N Engl J Med. 1980 Jan 3;302(1):57. doi: 10.1056/NEJM198001033020114. No abstract available.
Goel R, Majeed F, Vogel R, Corretti MC, Weir M, Mangano C, White C, Plotnick GD, Miller M. Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner. Am J Cardiol. 2007 Mar 1;99(5):743-4. doi: 10.1016/j.amjcard.2006.09.127. Epub 2007 Jan 11.
Handler JB, Asay RW, Warren SE, Shea PM. Symptomatic coronary artery disease in a marathon runner. JAMA. 1982 Aug 13;248(6):717-9. No abstract available.
Hellerstein HK, Moir TW. Distance running in the 1980s: cardiovascular benefits and risks. Cardiovasc Clin. 1985;15(2):75-86.
Lehtonen A, Viikari J. Coronary-artery disease in marathon runners. N Engl J Med. 1980 Jan 3;302(1):57. No abstract available.
Maron BJ, Poliac LC, Roberts WO. Risk for sudden cardiac death associated with marathon running. J Am Coll Cardiol. 1996 Aug;28(2):428-31. doi: 10.1016/0735-1097(96)00137-4.
Mohlenkamp S, Bose D, Mahabadi AA, Heusch G, Erbel R. On the paradox of exercise: coronary atherosclerosis in an apparently healthy marathon runner. Nat Clin Pract Cardiovasc Med. 2007 Jul;4(7):396-401. doi: 10.1038/ncpcardio0926.
Mohlenkamp S, Schmermund A, Kroger K, Kerkhoff G, Brocker-Preuss M, Adams V, Hensel M, Kiefer D, Lehmann N, Moebus S, Leineweber K, Elsenbruch S, Barkhausen J, Halle M, Hambrecht R, Siegrist J, Mann K, Budde T, Jockel KH, Erbel R. Coronary atherosclerosis and cardiovascular risk in masters male marathon runners. Rationale and design of the "marathon study". Herz. 2006 Sep;31(6):575-85. doi: 10.1007/s00059-006-2879-6.
Neilan TG, Januzzi JL, Lee-Lewandrowski E, Ton-Nu TT, Yoerger DM, Jassal DS, Lewandrowski KB, Siegel AJ, Marshall JE, Douglas PS, Lawlor D, Picard MH, Wood MJ. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation. 2006 Nov 28;114(22):2325-33. doi: 10.1161/CIRCULATIONAHA.106.647461. Epub 2006 Nov 13.
Noakes TD. Heart disease in marathon runners: a review. Med Sci Sports Exerc. 1987 Jun;19(3):187-94.
Roberts WO, Maron BJ. Evidence for decreasing occurrence of sudden cardiac death associated with the marathon. J Am Coll Cardiol. 2005 Oct 4;46(7):1373-4. doi: 10.1016/j.jacc.2005.07.008. No abstract available.
Schuchert A, Puschel K, Kupper W, Schafer H, Bleifeld W. [Sudden heart death in a long distance runner during a marathon]. Z Kardiol. 1989 Apr;78(4):276-80. German.
Rowe WJ. A world record marathon runner with silent ischemia without coronary atherosclerosis. Chest. 1991 May;99(5):1306-8. doi: 10.1378/chest.99.5.1306.
Tunstall Pedoe DS. Marathon cardiac deaths : the london experience. Sports Med. 2007;37(4-5):448-50. doi: 10.2165/00007256-200737040-00046.
Related Links
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The Minneapolis Heart Institute Foundation improves cardiovascular health through clinical research and education
The Minneapolis Heart Institute® is recognized internationally as one of the world's leading providers of heart and vascular care
Other Identifiers
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Identifier Type: -
Identifier Source: org_study_id