Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
NCT ID: NCT06480695
Last Updated: 2025-07-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2025-07-01
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
QUADRUPLE
Study Groups
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Nitrate-Rich Beetroot Juice + High Intensity Exercise (HIE)
Participants assigned to this group will be instructed to consume 1 bottle of nitrate-rich beetroot juice (\~400mg of nitrate each) 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 15-17 based on the participant's VO2peak test.
Nitrate-Rich Beetroot Juice
subjects will consume 1 bottle of nitrate-rich beetroot juice (\~400mg of nitrate each) 2x a day
High Intensity Exercise
exercise at an intensity midway between the lactate threshold and VO2peak, from the screening test at an RPE of \~ 15-17
Nitrate-Depleted Placebo Beetroot Juice + High Intensity Exercise (HIE)
Participants assigned to this group will be instructed to consume 1 bottle of nitrate-depleted beetroot juice 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 15-17 based on the participant's VO2peak test.
High Intensity Exercise
exercise at an intensity midway between the lactate threshold and VO2peak, from the screening test at an RPE of \~ 15-17
Nitrate-Depleted Placebo Beetroot Juice
Subjects will consume 1 bottle of nitrate-depleted beetroot juice 2x a day
Nitrate-Rich Beetroot Juice + Moderate Intensity Exercise (MIE)
Participants assigned to this group will be instructed to consume 1 bottle of nitrate-rich beetroot juice (\~400mg of nitrate each) 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 10-12 based on the participant's VO2peak test.
Nitrate-Rich Beetroot Juice
subjects will consume 1 bottle of nitrate-rich beetroot juice (\~400mg of nitrate each) 2x a day
Moderate Intensity Exercise
exercise at the RPE at LT associated an \~ RPE of 10-12
Nitrate-Depleted Placebo Beetroot Juice + Moderate Intensity Exercise (MIE)
Participants assigned to this group will be instructed to consume 1 bottle of nitrate-depleted beetroot juice 2x a day (morning a night) starting 2-hours before the first exercise session. Participants will complete a supervised bout of exercise on a treadmill 3x a week for 1-month. Participants will exercise at an RPE of 10-12 based on the participant's VO2peak test.
Moderate Intensity Exercise
exercise at the RPE at LT associated an \~ RPE of 10-12
Nitrate-Depleted Placebo Beetroot Juice
Subjects will consume 1 bottle of nitrate-depleted beetroot juice 2x a day
Interventions
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Nitrate-Rich Beetroot Juice
subjects will consume 1 bottle of nitrate-rich beetroot juice (\~400mg of nitrate each) 2x a day
High Intensity Exercise
exercise at an intensity midway between the lactate threshold and VO2peak, from the screening test at an RPE of \~ 15-17
Moderate Intensity Exercise
exercise at the RPE at LT associated an \~ RPE of 10-12
Nitrate-Depleted Placebo Beetroot Juice
Subjects will consume 1 bottle of nitrate-depleted beetroot juice 2x a day
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Sedentary (does not exercise regularly or less than 2 bouts of exercise per week)
* No major changes in medication in the last 3 months
Exclusion Criteria
* Weight unstable (loss/gain of more than 3kg in the past 3 months)
* Any medical condition that prevents the subject from exercising safely
* Hormone replacement therapy (current or within last 3 months)
* Diabetes
* Currently or recently on vasoactive medications (i.e., calcium channel blockers, statins, ACE or renin inhibitors, ARBs, nitrates, alpha- or beta-blockers, diuretics, proton pump inhibitors, etc.)
* Oral antibiotic use within previous four weeks
* Oral disease or poor oral health as determined by the Oral Health Questionnaire
* Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
45 Years
75 Years
FEMALE
Yes
Sponsors
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University of Virginia
OTHER
Responsible Party
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Jason Allen
Professor
Principal Investigators
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Jason Allen, PhD
Role: PRINCIPAL_INVESTIGATOR
UVA
Locations
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Student Health and Wellness Building - Department of Kinesiology
Charlottesville, Virginia, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HSR231665
Identifier Type: -
Identifier Source: org_study_id
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