Resistance Exercise Training on Vascular and Physical Function in Postmenopausal Women

NCT ID: NCT06958965

Last Updated: 2025-05-06

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 32 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-07-01
• Study Completion Date: 2026-04-14

Brief Summary

Postmenopausal women often face risks of vascular dysfunction and muscle deterioration due to estrogen deficiency. These changes significantly increase the risk of cardiovascular disease and mortality. Previous studies have shown a significant positive correlation between vascular endothelial function and muscle strength. Moreover, muscle strength is a stronger predictor of mortality than muscle mass and is closely associated with the maintenance of functional independence in daily life. However, studies investigating the effects of whole-body progressive resistance training on vascular function and physical performance in postmenopausal women remain limited. This study aims to examine changes in vascular function and muscle strength in postmenopausal women following a whole-body progressive resistance training program.

Conditions

Postmenopausal Women

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Effects of Resistance Exercise Training on Vascular Function and Physical Performance in Postmenopau

This study involved a 12-week group-based resistance training program, with two sessions per week, each lasting 90 to 120 minutes. The exercise intensity targeted 40-70% of participants' one-repetition maximum (1RM) or a moderate level (approximately a score of 3 on the Modified Borg RPE scale). Equipment used included dumbbells, kettlebells, grip rings, body bars, resistance bands, step platforms, and sandbags, following a three-phase structured exercise model.

Group Type: EXPERIMENTAL

Resistance exercise training

Intervention Type: OTHER

The total duration of the training was 12 weeks, with a frequency of two sessions per week. Each session lasted approximately 90 to 120 minutes. The exercise intensity was set at 40-70% of the participants' one-repetition maximum (1RM), or adjusted based on the Modified Borg Rating of Perceived Exertion (RPE), targeting a moderate intensity level (approximately a score of 3).

Control

Participants in the control group did not undergo any resistance training intervention and were advised to continue their usual daily routines, dietary patterns, and prescribed medications throughout the study period.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Resistance exercise training

The total duration of the training was 12 weeks, with a frequency of two sessions per week. Each session lasted approximately 90 to 120 minutes. The exercise intensity was set at 40-70% of the participants' one-repetition maximum (1RM), or adjusted based on the Modified Borg Rating of Perceived Exertion (RPE), targeting a moderate intensity level (approximately a score of 3).

Intervention Type: OTHER

Other Intervention Names

resistance training

Eligibility Criteria

Inclusion Criteria

Participants were eligible for the study if they met the following criteria:

1. Postmenopausal women aged between 55 and 70 years;

2. Body mass index (BMI) less than 30 kg/m²;

3. At least one year since menopause;

4. Able to live independently in the community;

5. Able to communicate independently in Mandarin or Taiwanese.

Exclusion Criteria

Participants were excluded if they met any of the following conditions:

1. Acute musculoskeletal injuries within the past month (e.g., acute inflammation, fractures, sprains, contusions, or joint implants);

2. Diagnosed central or peripheral nervous system disorders affecting exercise participation (e.g., stroke, dementia, Parkinson's disease, autonomic dysfunction);

3. History of serious cardiac conditions within the past six months (e.g., coronary stenting, pacemaker implantation, peripheral or cerebral vascular reconstruction);

4. Presence of peripheral vascular diseases (e.g., peripheral artery disease, venous thrombosis);

5. Hormone therapy within the past six months;

6. Currently taking beta-blockers, anti-inflammatory drugs, or anticoagulant medications;

7. Currently participating in any other structured exercise training programs.

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

National Yang Ming Chiao Tung University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

NYCU114053AE

Identifier Type: -

Identifier Source: org_study_id