The Influence of Hormone Replacement Therapy and Supervised Exercise Training on Body Composition, Cardiovascular Risk and Insulin Sensitivity in Postmenopausal Women
NCT ID: NCT05831709
Last Updated: 2025-11-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
390 participants
INTERVENTIONAL
2023-05-12
2028-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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Supervised training + immediate hormone substitution therapy per SOC
Exercise program
The intervention consists of a supervised exercise program
Hormonal substitution therapy per SOC
Subjects take hormonal substitution therapy per standard of care
Supervised training + delayed hormone substitution therapy per SOC
Exercise program
The intervention consists of a supervised exercise program
Delayed supervised training + immediate hormone substitution therapy per SOC
Hormonal substitution therapy per SOC
Subjects take hormonal substitution therapy per standard of care
Supervised training
Subjects who will start hormone substitution therapy in standard of care can participate in the trial and have 50% chance to be randomised in the exercise group.
Exercise program
The intervention consists of a supervised exercise program
No supervised training
Subjects who will start hormone substitution therapy in standard of care can participate in the trial and have 50% chance to be randomised in the non-exercise group.
No interventions assigned to this group
Control group
Subjects with menopausal complaints who do not want hormone substitution therapy or supervised training, can also participate in the trial.
No interventions assigned to this group
Interventions
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Exercise program
The intervention consists of a supervised exercise program
Hormonal substitution therapy per SOC
Subjects take hormonal substitution therapy per standard of care
Eligibility Criteria
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Inclusion Criteria
* Indication for hormonal substitution therapy (except for the control group)
* Good general health
* BMI: 20-30 kg/m2
* Only the use of cholesterol-, blood pressure- or/and thyroid-regulating medication is permitted
45 Years
65 Years
FEMALE
No
Sponsors
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University Hospital, Ghent
OTHER
Responsible Party
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Locations
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Ghent University Hospital - Women's Clinic
Ghent, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Role: primary
Other Identifiers
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ONZ-2023-0015
Identifier Type: -
Identifier Source: org_study_id
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