Investigate the Relationship Between Exercise Training and Recovery Ratio to Improve Physical Performance and Health Status

NCT ID: NCT05893641

Last Updated: 2024-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-01

Study Completion Date

2025-07-31

Brief Summary

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This study aims to investigate the effectiveness of various recovery strategies (such as longer recovery periods or reduced exercise intensity) in optimizing both physical performance and overall health status. Furthermore, the study will explore the potential of using changes in blood and urinary markers as indicators for assessing recovery status.

This study will assess whether extending recovery periods between exercise sessions and reducing the volume of exercise training can enhance the recovery process and enhance performance and health-related markers, relative to a control group.

One hundred-fifth young males will be recruited to participate in a single-center, parallel-group, randomized, well-controlled, superiority trial for 8 weeks of high-volume exercise training.

A single-center, parallel-group, randomized, well-controlled, superiority trial will be conducted among 150 physically active young males. Participants will undergo an 8-week high-volume exercise during base training program, which they will be randomly assigned to one of three groups: (1) a control group, which will follow the standard exercise regimen of 35 hours/week (n = 50); (2) a less exercise volume group, which will reduce exercise volume by 15% to 30 hours/week (n = 50); and (3) an extended recovery group, which will perform the same volume of exercise as the control group (35 hours/week), but with longer recovery intervals between exercises (n = 50). The intervention will take place at the Ministry of Defense training platform.

All study measurements will be taken at baseline and throughout the study. Body composition will be assessed using multichannel bioelectrical impedance (Seca). Continuously monitor (Garmin) will be used to evaluate heart rate and heart rate variability. Fasting blood samples will be used to examine inflammatory, lipid, glycemic, and endocrine markers. Physical performance will be assessed by several validated assessments, including handgrip, maximal voluntary contraction, Wingate test, Isometric Mid-Thigh Pull (IMTP), counter movement jump (CMJ) and maximal oxygen consumption (VO2max).

Detailed Description

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The primary aim will be to determine the effect of different recovery strategies during 8 weeks of well-controlled, high-volume, large-scale, exercise training on the immune system (a), cardio-metabolic markers (b), and endocrine response (c).

Secondary aims will include: (1) To determine the effect of different recovery strategies during 8 weeks of well-controlled, high-volume, large-scale, exercise training on body strength (a), aerobic capacity (b), and body composition (c).

After baseline measurements, participants will be randomized 1:1:1 into one of three groups for 8 weeks: (1) a control group, which will follow the standard exercise regimen of 35 hours/week (n = 50); (2) a less exercise volume group, which will reduce exercise volume by 15% to 30 hours/week (n = 50); and (3) an extended recovery group, which will perform the same volume of exercise as the control group (35 hours/week), but with longer recovery intervals between exercises (n = 50).

Changes in health indices will be assessed by cardiometabolic, endocrine, and immune blood markers and body composition assessment at baseline (T0) after, 4 (T4), and 8 (T8) weeks of the intervention. Aerobic capacity, anaerobic threshold, and strength measurements will be used to determine changes in performance at T0, T4, and T8.

Conditions

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Exercise Recovery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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A regular training volume

They will maintain their training volume of 35 h/week

Group Type ACTIVE_COMPARATOR

A regular training volume

Intervention Type BEHAVIORAL

Participate will maintain their training volume of 35 h/week

A lower exercise volume group

They will conduct 85% of the control group weekly training volume (i.e., 30h/week)

Group Type ACTIVE_COMPARATOR

A lower exercise volume group

Intervention Type BEHAVIORAL

Participate will conduct 85% of the control group weekly training volume (i.e., 30h/week)

A longer rest group

They will maintain the 35 h/week of exercise training, but with longer rest between exercise sessions

Group Type ACTIVE_COMPARATOR

A longer rest group

Intervention Type BEHAVIORAL

Participate will maintain the 35 h/week of exercise training

Interventions

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A regular training volume

Participate will maintain their training volume of 35 h/week

Intervention Type BEHAVIORAL

A lower exercise volume group

Participate will conduct 85% of the control group weekly training volume (i.e., 30h/week)

Intervention Type BEHAVIORAL

A longer rest group

Participate will maintain the 35 h/week of exercise training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Highly active participants
* Healthy
* Candidates for security course in the Ministry of Defense

Exclusion Criteria

* Cardiopulmonary diseases (e.g., recent myocardial infarction or unstable angina)
* Musculoskeletal or neuromuscular impairments that preclude exercise training
* Cognitive impairments
* Use of drugs that affect bone or muscle metabolism (mainly steroids)
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tel Aviv University

OTHER

Sponsor Role lead

Responsible Party

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Gepner Yftach

Principal Investigator - Ph.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Tel Aviv University

Tel Aviv, Other, Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Yftach Gepner, PhD

Role: CONTACT

+972733804726

Facility Contacts

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Yftach Gepner, PhD

Role: primary

+972733804726

Other Identifiers

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0006524-1

Identifier Type: -

Identifier Source: org_study_id

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