Association Between Fibrinogen-to-albumin Ratio and Delirium After Deep Brain Stimulation Surgery in Parkinson's Disease

NCT ID: NCT05833308

Last Updated: 2023-05-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

226 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2023-01-31

Brief Summary

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Postoperative delirium (POD) remains one of the most common neuropsychiatric complications after deep brain stimulation (DBS) surgery. The fibrinogen-to-albumin ratio (FAR) has been shown to significantly correlate with prognosis of many diseases associated with inflammation, but the relationship between FAR and POD is unclear. The investigators aimed to investigate the association between POD and FAR in Parkinson's disease (PD) patients receiving DBS surgery. For this aim, the present study was conducted to provide a new method for the early recognition and perioperative management of delirium after DBS surgery in PD patients.

Detailed Description

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Conditions

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Parkinson Disease Deep Brain Stimulation Postoperative Delirium

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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POD group

Patients who were determined to have incident postoperative delirium by a positive confusion assessment method (CAM) questionnaire after operation were defined as the POD group.

No interventions assigned to this group

Non-POD group

Patients who did not suffer from delirium after surgery consisted of the Non-POD group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Over 55 years old
* American Society of Anesthesiologists (ASA) physical status I-III
* Bilateral subthalamic nucleus deep brain stimulation surgery

Exclusion Criteria

* Preoperative delirium
* Missing preoperative laboratory parameters on fibrinogen or albumin
* Persistent infectious diseases
* Coagulopathy and autoimmune-illness or malignancies
Minimum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Changhai Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wen-bin Lu, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Changhai Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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POD-FAR

Identifier Type: -

Identifier Source: org_study_id

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