Mechanical Power Normalized to Compliance in ARDS

NCT ID: NCT05761626

Last Updated: 2025-04-30

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 39 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-03-01
• Study Completion Date: 2023-02-10

Brief Summary

Mechanical power (MP) is a summary variable, which includes static and dynamic respiratory parameters, is associated with ventilator-induced lung injury. MP is transferred primarily to smaller functional lung size, often referred to as "baby lung" (BL). Functional lung size (BL) is associated with respiratory system compliance (Crs). For this reason, MP normalized to Crs (MP/Crs) could be an important parameter to evaluate. The objectives of this study were to compare variables according to the MP/Crs cut-off point and to identify the MP components associated with MP/Crs.

Detailed Description

In patients with acute respiratory distress syndrome (ARDS), undergoing mechanical ventilation (MV), each respiratory cycle transfers a specific amount of mechanical energy to the lung, aimed to expand and overcome airway resistance. The total mechanical energy multiplied by the respiratory rate (RR) defines the mechanical power (MP). It has been hypothesized that a smaller functional lung size, often referred to as "baby lung" (BL), increases mechanical energy transfer that exacerbates lung damage. Functional lung size (BL) is associated with respiratory system compliance (Crs). Whatever the size of this operational BL, protective ventilation strategies should be aimed at preserving its size and functionality, to avoid ventilator-induced lung injury (VILI). For this reason, MP normalized to Crs (MP/Crs) could be an important parameter to evaluate. Preclinical studies have found that VILI arises primarily from a combination of MP components and not from any of its components individually. We believe that MP/Crs should have the same behavior in relation to MP components as a whole. Therefore, the objectives of this study are to compare variables according to the MP/Crs cut-off point and to identify the MP components associated with MP/Crs.

Conditions

Acute Respiratory Distress Syndrome

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Patients with MP/Crs < = 0.48 j/min/ml/cmH2O

Patients with MP/Crs \< = 0.48 j/min/ml/cmH2O

MP/Crs assessment < = 0.48 J/min/ml/cmH2O

Intervention Type: OTHER

Assessment of the ventilatory variables according to the MP/Crs value (\<= or \> 0.48 J/min/ml/cmH2O)

Patients with MP/Crs > 0.48 j/min/ml/cmH2O

Patients with MP/Crs \> 0.48 j/min/ml/cmH2O

No interventions assigned to this group

Interventions

MP/Crs assessment < = 0.48 J/min/ml/cmH2O

Assessment of the ventilatory variables according to the MP/Crs value (\<= or \> 0.48 J/min/ml/cmH2O)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• patients who have been receiving mechanical ventilation (MV) and have been defined as with ARDS according to the Berlin definition

Exclusion Criteria

• patients with chronic pulmonary disease
• patients with an expected duration of MV shorter than 48 h
• patients with a high risk of death within 3 months for reasons other than ARDS
• patients having made the decision to withhold life-sustaining treatment.

• Minimum Eligible Age: 15 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ramos Mejía Hospital

OTHER

Sponsor Role: lead

Responsible Party

Roberto Santa Cruz

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Hospital Regional Rio Gallegos

Río Gallegos, Santa Cruz Province, Argentina

Countries

Argentina

References

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Other Identifiers

Universidad de Magallanes

Identifier Type: -

Identifier Source: org_study_id