Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults

NCT ID: NCT05760066

Last Updated: 2023-03-08

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-08-01
• Study Completion Date: 2024-08-01

Brief Summary

The goal of this clinical trial is to compare the effects of resistance training (RT) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals. The main questions it aims to answer are:

• To determine if performing RT prior to a period of disuse enhances the regain of strength, skeletal muscle size, and skeletal muscle quality while performing RT after a period of disuse.
• To determine if performing RT prior to a period of disuse dampens the maladaptive effects of disuse on muscle size, muscle quality, and strength.
• To determine the anabolic and proteolytic mechanisms underpinning the observed outcomes.

Participants will:

1. Perform either 6 weeks of resistance training or maintain an untrained lifestyle

2. Perform 2 weeks of limb immobilization induced disuse of a randomized leg

3. Perform 6 weeks of resistance training

Researchers will compare the resistance training preconditioning condition vs the non-trained condition to see if resistance training prior to a period of disuse is beneficial during the disuse period and in the return to training period on skeletal muscle size, strength, and underpinning molecular markers.

Conditions

Atrophy, Disuse; Atrophy, Muscular

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Resistance Training Preconditioning (PRECON)

This group will perform:

1. 6 weeks of lower body focused resistance training

2. 2 weeks of locking brace-induced immobilization of a randomized leg

3. 6 weeks of lower body focused resistance training

Group Type: EXPERIMENTAL

Resistance Training Preconditioning

Intervention Type: OTHER

Resistance training prior to disuse-induced atrophy followed by another period of resistance training

Control (CTL)

This group will perform:

1. 6 weeks of activities of daily living (no training)

2. 2 weeks of locking brace-induced immobilization of a randomized leg

3. 6 weeks of lower body focused resistance training

Group Type: ACTIVE_COMPARATOR

Control

Intervention Type: OTHER

Activities of daily living prior to disuse-induced atrophy followed by a period of resistance training

Interventions

Resistance Training Preconditioning

Resistance training prior to disuse-induced atrophy followed by another period of resistance training

Intervention Type: OTHER

Control

Activities of daily living prior to disuse-induced atrophy followed by a period of resistance training

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Between the ages of 18-30
• Free from medical implants in lower extremity that would interfere with low-dose radiation
• Are not allergic to ultrasound gel or Lidocaine
• Have no or minimal experience with resistance training (less than 1 training session/week for a 1 year period)

Exclusion Criteria

• Have been exposed to medically necessary radiation in the past 12 months other than dental x-rays
• Have known overt cardiovascular or metabolic disease
• Have a medical condition that would contraindicate participating in an exercise program or donating a skeletal muscle biopsy (e.g. blood clotting disorder, taking blood thinners, etc.)
• Are undergoing medical treatment for a disease that would interfere physiologically or logistically with study outcomes and/or protocols (e.g. undergoing chemotherapy and/or radiation for cancer treatment)
• Have consumed supplemental protein, creatine, and/or agents that affect hormone status (e.g. testosterone, growth hormone boosters, etc.) within the previous 2 months.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Auburn University

OTHER

Sponsor Role: lead

Responsible Party

Michael Roberts

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Michael D Roberts, PhD

Role: CONTACT

mdr0024@auburn.edu

334-844-1925

John M Michel, MS

Role: CONTACT

michel@auburn.edu

2059077830

Other Identifiers

MDR0823

Identifier Type: -

Identifier Source: org_study_id