Effects of Unloading on Muscle Mass

NCT ID: NCT00936039

Last Updated: 2013-07-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2013-06-30

Brief Summary

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In the present study, the effects of 3 weeks of unloading on muscle mass and muscle fiber characteristics will be determined. In addition, the effects of 6 weeks of recovery will be assessed.

Detailed Description

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Conditions

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Immobilization Physical Inactivity

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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unloading

2 weeks of unloading

Group Type EXPERIMENTAL

unloading

Intervention Type BEHAVIORAL

2 weeks of unloading of a single leg

Interventions

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unloading

2 weeks of unloading of a single leg

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy
* BMI \< 30 kg/m2

Exclusion Criteria

* Use of medication that may affect haemostasis
* Subjects with (recent) musculoskeletal/orthopaedic disorders known to affect the outcome of the study or that compromise their ability to walk with crutches
* Subjects with metal implants in their lower limbs
* Subjects with known cardiovascular and/or haemostasis disorders
* Subjects with known severe hypertension
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Luc JC van Loon, PhD

Role: PRINCIPAL_INVESTIGATOR

Maastricht UMC

Locations

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Maastricht University Medical Centre

Maastricht, , Netherlands

Site Status

Countries

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Netherlands

References

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Gorissen SHM, Trommelen J, Kouw IWK, Holwerda AM, Pennings B, Groen BBL, Wall BT, Churchward-Venne TA, Horstman AMH, Koopman R, Burd NA, Fuchs CJ, Dirks ML, Res PT, Senden JMG, Steijns JMJM, de Groot LCPGM, Verdijk LB, van Loon LJC. Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. J Nutr. 2020 Aug 1;150(8):2041-2050. doi: 10.1093/jn/nxaa024.

Reference Type DERIVED
PMID: 32069356 (View on PubMed)

Other Identifiers

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MEC-09-3-011

Identifier Type: -

Identifier Source: org_study_id

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