Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
21 participants
INTERVENTIONAL
2021-06-14
2023-04-30
Brief Summary
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Detailed Description
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The aim of this study is to investigate the acute responses to moderate-heavy resistance exercise in DM1-patients. We aim to establish a timeline for recovery of muscle strength, measured as maximal voluntary contraction. In line with this, we want to investigate if any muscular damage has occurred with both direct and indirect measures, and possible mechanisms leading to muscle damage, i.e. impaired Ca2+ handling.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
OTHER
SINGLE
Study Groups
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DM1-Ex
Moderate-heavy resistance exercise of one leg in DM1-patients
Moderate-Heavy Resistance Exercise
Leg press: 3 x 8 repetitions at 75% of 1 repetition maximum, 3 minutes rest between sets.
Knee extension: 3 x 6 repetitions at 85% of 1 repetition maximum, 3 minutes rest between sets.
DM1-Rest
Control leg (i.e. no exercise) in DM1-patients
No interventions assigned to this group
Ctrl-Ex
Moderate-heavy resistance exercise of one leg in healthy participants
Moderate-Heavy Resistance Exercise
Leg press: 3 x 8 repetitions at 75% of 1 repetition maximum, 3 minutes rest between sets.
Knee extension: 3 x 6 repetitions at 85% of 1 repetition maximum, 3 minutes rest between sets.
Ctrl-Rest
Control leg (i.e. no exercise) in healthy participants
No interventions assigned to this group
Interventions
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Moderate-Heavy Resistance Exercise
Leg press: 3 x 8 repetitions at 75% of 1 repetition maximum, 3 minutes rest between sets.
Knee extension: 3 x 6 repetitions at 85% of 1 repetition maximum, 3 minutes rest between sets.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Injuries to muscle-skeletal-system that prevents resistance exercise
* Severe affection of the cardiovascular system
* Cognitive affection
* Lives more than one hour from test site
18 Years
55 Years
ALL
Yes
Sponsors
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Oslo University Hospital
OTHER
University of Southern Denmark
OTHER
University of Copenhagen
OTHER
Maastricht University
OTHER
University of Oslo
OTHER
Norwegian School of Sport Sciences
OTHER
Responsible Party
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Truls Raastad
Professor
Principal Investigators
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Truls Raastad, PhD
Role: PRINCIPAL_INVESTIGATOR
Norwegian School of Sport Sciences
Locations
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Norwegian School of Sport Sciences
Oslo, , Norway
Countries
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Other Identifiers
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STYRK DM1
Identifier Type: -
Identifier Source: org_study_id