Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation of CT Guided Bone Biopsy
NCT ID: NCT05752903
Last Updated: 2023-09-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
60 participants
INTERVENTIONAL
2023-03-04
2023-09-15
Brief Summary
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Detailed Description
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Propofol is a non-barbiturate hypnotic and sedative. It facilitates gamma-aminobutyric acid mediated inhibitory neurotransmission. It's known to have anti-emetic, antipruritic, anticonvulsant and amnestic effects. Despite being effective and potent, Propofol's main disadvantages is its dose-dependent hypotension and respiratory depression .Ketamine is a phencyclidine derivative which acts as a N-methyl-D-aspartate (NMDA) receptor antagonist. It is a dissociative anesthetic and provides some analgesia. It maintains airway reflexes and spontaneous respiration. Combining Propofol and ketamine preserves the sedative and analgesic efficacy while reducing their adverse effects. Dexmedetomidine is a highly selective α2-agonist. It is eight times more specific compared with clonidine. It has a perioperative anxiolytic, sedative properties as well as some analgesic properties .Dexmedetomidine is usually used for mild to moderate sedation and Propofol could be added to deepen the level of sedation
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Dexmedetomidine-propofol
Dexmedetomidine-propofol bolus will be administered then Dexmedetomidine-propofol infusion continued during the procedure
Dexmedetomidine-propofol
1 microgram/kg dexmedetomidine+2.5 mg/kg propofol intravenous (IV) bolus, 0.5 microgram g/kg/h dexmedetomidine+2.5 mg/kg/h propofol infusion
ketamine-propofol
ketamine-propofol bolus will be administered then Dexmedetomidine-propofol infusion continued during the procedure
Ketamine-Propofol
1 mg/kg ketamine+2.5 mg/kg propofol iv bolus, 0.25 mg/kg/h ketamine+2.5mg/kg/h propofol infusion
Interventions
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Dexmedetomidine-propofol
1 microgram/kg dexmedetomidine+2.5 mg/kg propofol intravenous (IV) bolus, 0.5 microgram g/kg/h dexmedetomidine+2.5 mg/kg/h propofol infusion
Ketamine-Propofol
1 mg/kg ketamine+2.5 mg/kg propofol iv bolus, 0.25 mg/kg/h ketamine+2.5mg/kg/h propofol infusion
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age between 18 to 60 years old
* American Society of Anesthesiologists (ASA) physical I-III
* Scheduled for CT guided bone biopsy with sedation.
Exclusion Criteria
* kidney failure
* Bleeding diathesis Allergy to drugs to be used
18 Years
60 Years
ALL
No
Sponsors
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National Cancer Institute, Egypt
OTHER
Responsible Party
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Principal Investigators
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Ahmed Salah abdelgalil, MD
Role: PRINCIPAL_INVESTIGATOR
National Cancer Institute (NCI)
Locations
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National cancer institute
Cairo, , Egypt
Countries
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Other Identifiers
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AP2207-50109
Identifier Type: -
Identifier Source: org_study_id
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