Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs
NCT ID: NCT04928300
Last Updated: 2026-01-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE3
60 participants
INTERVENTIONAL
2021-06-12
2027-07-25
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Group D
Dexmedetomidine infusion IV for 5 days.
Dexmedetomidine
low dose dexmedetomidine infusion 0.2 µ/kg/hour IV for 5 days.
Group C
The same dose and duration of normal saline will be given.
0.9% saline
the same dose and duration of normal saline will be given for 5 days.
Interventions
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Dexmedetomidine
low dose dexmedetomidine infusion 0.2 µ/kg/hour IV for 5 days.
0.9% saline
the same dose and duration of normal saline will be given for 5 days.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Traumatic multiple fracture ribs 3 ribs or more, who will be subjected to thorough assessments including chest 3D-CT
* Undergoing conservative treatment (chest strappings)
* Intractable pain with visual analogue scale (VAS) over 6 after traditional therapies
* Glasgow Coma Scale (GCS) ≥ 13.
Exclusion Criteria
* Serious head trauma with a Glasgow coma scale lower than 13
* Mechanically ventilated patients
* Massive hemothorax
* Injury to the trachea or bronchus with requirement for immediate surgery
* Dementia
* Use of corticosteroids during ICU stay
* Sepsis
* Continued use of neuromuscular blocking agents and aminoglycosides antibiotic use as they are known risk factors for ICU-acquired weakness and any known hypersensitivity
* Contraindication to the study drugs.
18 Years
65 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Omar Makram Soliman
Lecturer of anesthesia and ICU
Principal Investigators
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Omar Soliman, MD
Role: STUDY_DIRECTOR
Assiut University
Locations
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Assiut university hospital
Asyut, Assuit, Egypt
Countries
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Central Contacts
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Facility Contacts
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References
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Bossolasco M, Bernardi E, Fenoglio LM. Continuous serratus plane block in a patient with multiple rib fractures. J Clin Anesth. 2017 May;38:85-86. doi: 10.1016/j.jclinane.2016.12.015. Epub 2017 Jan 30. No abstract available.
Other Identifiers
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17300614
Identifier Type: -
Identifier Source: org_study_id
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