Effect of Mulligans Mobilization With Movement in Osteoarthritis Knee.

NCT ID: NCT05577403

Last Updated: 2025-09-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-11-05
• Study Completion Date: 2023-11-14

Brief Summary

To evaluate the effect of Mulligan's mobilization with movement in osteoarthritis of the knee.

Detailed Description

Patients with knee OA diagnosed at the orthopaedic clinic of Tumair general hospital and referred to the physiotherapy department who attended the rehabilitation centre of Majmaah university will be recruited.

Patients will be excluded if they have had a knee or hip injury, sensory deficits in the lower extremity, a history of lower-extremity surgery, a history of a quadriceps or hamstring muscle injury, low back-related leg pain, or any contraindication to manual therapy.

The protocol was submitted to and approved by the Rehabilitation Research Chair, King Saud University Research Ethics Committee (RRC-2021-17)

Participants will be requested to sign a written informed consent form approved by the institutional ethics committee. A total of 60 participants were randomly assigned to group A (experimental group): Mulligan's mobilization with movement MWM added isometric strength training, and group B (control group): Sham MWM added isometric strength training. Pre and post-test readings were taken at baseline, week 2, and week 4, respectively. The outcome measures for this study will be maximal voluntary isometric contraction of quadriceps strength (measured by ISOMOVE dynamometer), ROM, and Western Ontario and McMaster universities osteoarthritis (WOMAC) index.

Conditions

Osteo Arthritis Knee

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Experimental Group

Mulligan's mobilization with movement added isometric strength training will be given 3 days a week for six weeks.

Group Type: EXPERIMENTAL

Mulligan's mobilization with movement MWM added isometric strength training

Intervention Type: BEHAVIORAL

Mulligan's mobilization with movement added isometric exercise:

the participants in the experimental group will receive a Mulligan's mobilization with movement added isometric exercise.

Treatment will be given for the period of three weeks, for five days a week in both groups.

Data will be collected before intervention and after 2nd & 4th week of intervention.

Control Group

Mobilization-added isometric strength training will be given 3 days a week for six weeks.

Group Type: ACTIVE_COMPARATOR

Mulligan's mobilization with movement MWM added isometric strength training

Intervention Type: BEHAVIORAL

Mulligan's mobilization with movement added isometric exercise:

the participants in the experimental group will receive a Mulligan's mobilization with movement added isometric exercise.

Treatment will be given for the period of three weeks, for five days a week in both groups.

Data will be collected before intervention and after 2nd & 4th week of intervention.

Interventions

Mulligan's mobilization with movement MWM added isometric strength training

Mulligan's mobilization with movement added isometric exercise:

the participants in the experimental group will receive a Mulligan's mobilization with movement added isometric exercise.

Treatment will be given for the period of three weeks, for five days a week in both groups.

Data will be collected before intervention and after 2nd & 4th week of intervention.

Intervention Type: BEHAVIORAL

Other Intervention Names

Sham MWM added isometric strength training

Eligibility Criteria

Inclusion Criteria

• Patient with knee OA with radiological evidence of grade 2 or 3 of the Kellgren and Lawrence scale.
• Age between 40-65 years, unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included), and pain in and around the knee.

Exclusion Criteria

• Patient will be excluded, if they had any deformity of the knee, hip, or back, had any central or peripheral nervous system involvement.
• They had received steroids or intra-articular injection within the previous three months, uncooperative patients.

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

King Saud University

OTHER

Sponsor Role: collaborator

Majmaah University

OTHER

Sponsor Role: lead

Responsible Party

Shahnaz Hasan, PhD

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Shahnaz Hasan, PhD

Role: PRINCIPAL_INVESTIGATOR

Majmah University

Locations

Rehabilitation center, Majmaah University

Al Majma'ah, Riyadh Region, Saudi Arabia

Countries

Saudi Arabia

Other Identifiers

RRC-2021-17

Identifier Type: -

Identifier Source: org_study_id