Femoral Nerve Mobilization for Patients With Knee Osteoarthritis

NCT ID: NCT07329205

Last Updated: 2026-01-09

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-12-20
• Study Completion Date: 2026-02-25

Brief Summary

Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. There is a limited knowledge about using femoral nerve mobilization in treating patients with arthritic changes.

Objectives: This study will be designed to determine the efficacy of adding of femoral nerve mobilization on pain intensity, function, quality of life and central sensitization in patients with knee osteoarthritis Methods: Thirty patients (aged ≥50 years with KO Kellgren-Lawrence grades I-II) will be included in this study: Patients will randomly be assigned into two groups: group A will receive traditional physical therapy while group B will receive femoral nerve mobilization in addition to traditional physical therapy. Three sessions will be performed for four weeks by 3 session /week. Patients will be evaluated for pain intensity using the numerical rating scale (NRS), knee function by WOMAC scale, quality of life by 12-item Short Form Survey questionnaire (SF-12) and central sensitization by the Arabic version of central sensitization inventory (CSI).

Conditions

Knee Osteoarthristis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Control group

Traditional physical therapy

Group Type: ACTIVE_COMPARATOR

traditional physical therapy

Intervention Type: OTHER

stretching exercises for hamstring, calf muscles and iliotibial band in addition to isotonic exercise for hip extensors and abductors and isometric quadriceps exercise

Neural mobilization group

traditional physical therapy plus femoral nerve mobilization

Group Type: EXPERIMENTAL

traditional physical therapy

Intervention Type: OTHER

stretching exercises for hamstring, calf muscles and iliotibial band in addition to isotonic exercise for hip extensors and abductors and isometric quadriceps exercise

Femoral nerve mobilization

Intervention Type: OTHER

A physiotherapist guided the patients in performing active mobilization of the femoral nerve. The prescribed method for active neural mobilization involved assuming a prone position supported by the forearms with a slight extension of the spine, flexion of the knee, and extension of the cervical spine. This was followed by performing the opposite movement

Interventions

traditional physical therapy

stretching exercises for hamstring, calf muscles and iliotibial band in addition to isotonic exercise for hip extensors and abductors and isometric quadriceps exercise

Intervention Type: OTHER

Femoral nerve mobilization

A physiotherapist guided the patients in performing active mobilization of the femoral nerve. The prescribed method for active neural mobilization involved assuming a prone position supported by the forearms with a slight extension of the spine, flexion of the knee, and extension of the cervical spine. This was followed by performing the opposite movement

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• patients aged 50 years or older, diagnosed with KO according to theAmerican College of Rheumatology's criteria with knee pain, and grade I or II on the Kellgren-Lawrence radiographic scale

Exclusion Criteria

• individuals suffering from chronic conditions considered to be perpetuating factors (e.g., fibromyalgia)
• those with conditions causing lower extremity pain
• individuals who had taken analgesics within 24 h before evaluations
• those who had undergone corticosteroid or local anesthetic infiltration in the year prior to the study or during the follow-up period
• those using substances that could interfere with treatment
• those with a previous diagnosis of neuropathy (lumbosacral plexus) or myopathy
• those with contraindications to mobilization or exercise, and those with cognitive deficits (dementia, Alzheimer's).

• Minimum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Prince Sattam Bin Abdulaziz University

OTHER

Sponsor Role: lead

Responsible Party

Mohammad Moustafa Aldosoukki Hegazy

assisstant professor , department of health and rehabilitation sciences, college of applied medical siences

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Prince Sattam bin Abdulaziz University

Al Kharj, , Saudi Arabia

Countries

Saudi Arabia

Central Contacts

Mohammed Hegazy, Phd

Role: CONTACT

mohamed.mostafa@pt.cu.edu.eg

00966566169893 ext. 00966115886387

References

Pedersini P, Valdes K, Cantero-Tellez R, Cleland JA, Bishop MD, Villafane JH. Effects of Neurodynamic Mobilizations on Pain Hypersensitivity in Patients With Hand Osteoarthritis Compared to Robotic Assisted Mobilization: A Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2021 Feb;73(2):232-239. doi: 10.1002/acr.24103. Epub 2021 Jan 3.

Reference Type: RESULT

PMID: 31675184 (View on PubMed)

Yamasaki T, Nakajima H. [Glycogenosis type VII (glycogen storage disease type VII, human muscle-phosphofructokinase deficiency, Tarui's disease)]. Ryoikibetsu Shokogun Shirizu. 2001;(36):28-34. No abstract available. Japanese.

Reference Type: RESULT

PMID: 11596390 (View on PubMed)

Franklin-Tong VE. Signaling in pollination. Curr Opin Plant Biol. 1999 Dec;2(6):490-5. doi: 10.1016/s1369-5266(99)00017-5.

Reference Type: RESULT

PMID: 10607651 (View on PubMed)

Other Identifiers

RHPT/025/015

Identifier Type: -

Identifier Source: org_study_id