The Role of Endoscopic Ultrasound in Evaluation of Patients With Indefinite Cause of Bile Duct Dilatation
NCT ID: NCT05475964
Last Updated: 2022-07-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2022-09-09
2025-08-31
Brief Summary
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Detailed Description
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BDD with unclear etiology detected on trans abdominal ultrasound (TUS), computed tomography (CT), or magnetic resonance cholangiopancreatography (MRCP). Although, these imaging techniques have a good sensitivity and specificity in detecting biliary tract diseases, limitations are still present in the detection of intraductal small stones, ampullary lesions and small masses.
As regard TUS, overlying bowel gas and operator-dependence, often harshen an adequate visualization of the biliary duct to identify the etiology, and CT could miss tumors less than 2 cm in size, while the sensitivity of MRCP decreases in stones 3 mm or less in size.
Endoscopic ultrasound (EUS) enables high resolution views of the biliary tree as it joins the pancreatic duct and duodenum, so it helps detection of biliary pathologies difficult to be diagnosed by external radiograph. In addition, EUS is less invasive than the competitive endoscopic retrograde cholangiopancreatography (ERCP) as a diagnostic modality and it avoids the patients the post-ERCP pancreatitis which is a very common complication, as well as providing a unique opportunity of tissue sampling and staging of any detected malignant lesions.
Previously, EUS has proven it's high ability to the detect the stones in the extrahepatic ducts with a sensitivity as high as of 94% and specificity of 95%.
Besides, it's well performance in the evaluation of biliary strictures with a sensitivity 80%, and a specificity of 97% in detecting malignant biliary strictures.
When it comes to ampullary and pancreatic lesions, direct endoscopic visualization with a side-viewing endoscope can effectively evaluate the periampullary area and detect ampullary mass and diverticulum, as well examine the pancreas for chronic pancreatitis, masses, and cysts.
Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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patients with undiagnosed bile duct dilatation
patients with bile duct dilation detected by imaging studies without revealing definite cause of obstruction
Endoscopic ultrasound
Endoscopic ultrasound and biopsy intake of suspected lesions
Interventions
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Endoscopic ultrasound
Endoscopic ultrasound and biopsy intake of suspected lesions
Eligibility Criteria
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Inclusion Criteria
2. Common bile duct diameter of \>10 mm with prior cholecystectomy or \>7 mm without
Exclusion Criteria
\-
18 Years
ALL
Yes
Sponsors
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HMHamed
OTHER
Responsible Party
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HMHamed
Assistant lecturer of tropical medicine and gastroenterology
Principal Investigators
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Hager Hamed, Master
Role: PRINCIPAL_INVESTIGATOR
Assiut University
Locations
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AssiutU
Asyut, , Egypt
Countries
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Central Contacts
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Hamed
Role: CONTACT
Other Identifiers
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EUS in biliary dilatation
Identifier Type: -
Identifier Source: org_study_id
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