SpyGlass in Post Liver Transplant Biliary Complications.

NCT ID: NCT02543151

Last Updated: 2019-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2018-10-31

Brief Summary

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The purpose of this study is to describe SpyGlass choledochoscopy in patients with post orthotopic liver transplant (OLT) biliary strictures prior to endoscopic therapy and ductal changes after treatment stents.

Detailed Description

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A prospective observational clinical study to be conducted in Hospital Israelita Albert Einstein, a large open-access, private tertiary referral center.

Consecutive eligible patients with suspected post OLT biliary complications referred to endoscopic retrograde cholangiopancreatography (ERCP) will be considered to SpyGlass as follows.

In those patients with confirmed biliary stricture, SpyGlass direct choledochoscopy will be performed prior to endoscopic treatment with stents.

After final stent removal, choledochoscopy will be repeated to evaluate biliary ductal mucosa.

Conditions

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Liver Transplant Disorder Biliary Anastomosis Complication

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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SpyGlass Choledochoscopy procedure

Any patient referred to endoscopic management for biliary post liver transplant complication without previous treatment will be submitted to SpyGlass (direct visualization system) choledochoscopy procedure.

Group Type EXPERIMENTAL

SpyGlass (direct visualization system) choledochoscopy

Intervention Type PROCEDURE

SpyGlass (direct visualization system) choledochoscopy procedure will be performed pre and post biliary complication treatment

Interventions

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SpyGlass (direct visualization system) choledochoscopy

SpyGlass (direct visualization system) choledochoscopy procedure will be performed pre and post biliary complication treatment

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients referred to endoscopic management for biliary post liver transplant complication without previous treatment

Exclusion Criteria

* Patients referred to endoscopic management for biliary post liver transplant complication with any previous treatment.
* Below 18 years of age
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Israelita Albert Einstein

OTHER

Sponsor Role lead

Responsible Party

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FERNANDA PRATA MARTINS

Attending physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ANGELO P FERRARI, MD

Role: STUDY_DIRECTOR

Attending physician

FERNANDA P MARTINS, MD

Role: PRINCIPAL_INVESTIGATOR

Attending physician

Locations

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Hospital Israelita Albert Einstein

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

References

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Chen YK, Pleskow DK. SpyGlass single-operator peroral cholangiopancreatoscopy system for the diagnosis and therapy of bile-duct disorders: a clinical feasibility study (with video). Gastrointest Endosc. 2007 May;65(6):832-41. doi: 10.1016/j.gie.2007.01.025.

Reference Type BACKGROUND
PMID: 17466202 (View on PubMed)

Draganov PV, Lin T, Chauhan S, Wagh MS, Hou W, Forsmark CE. Prospective evaluation of the clinical utility of ERCP-guided cholangiopancreatoscopy with a new direct visualization system. Gastrointest Endosc. 2011 May;73(5):971-9. doi: 10.1016/j.gie.2011.01.003. Epub 2011 Mar 17.

Reference Type BACKGROUND
PMID: 21419408 (View on PubMed)

Tringali A, Lemmers A, Meves V, Terheggen G, Pohl J, Manfredi G, Hafner M, Costamagna G, Deviere J, Neuhaus H, Caillol F, Giovannini M, Hassan C, Dumonceau JM. Intraductal biliopancreatic imaging: European Society of Gastrointestinal Endoscopy (ESGE) technology review. Endoscopy. 2015 Aug;47(8):739-53. doi: 10.1055/s-0034-1392584. Epub 2015 Jul 6.

Reference Type BACKGROUND
PMID: 26147492 (View on PubMed)

Hasan M, Canipe A, Tharian B, Navaneethan U, Varadarajulu S, Hawes R. Digital cholangioscopy-directed removal of a surgical staple from a strictured bile duct. Gastrointest Endosc. 2015 Nov;82(5):958. doi: 10.1016/j.gie.2015.05.035. Epub 2015 Jun 25. No abstract available.

Reference Type BACKGROUND
PMID: 26117180 (View on PubMed)

Other Identifiers

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28005314.5.0000.0071

Identifier Type: OTHER

Identifier Source: secondary_id

1439-11

Identifier Type: -

Identifier Source: org_study_id

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