Fluorescent Cholangiography and Bile Duct Stones

NCT ID: NCT03530241

Last Updated: 2024-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-25

Study Completion Date

2023-08-01

Brief Summary

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Background. X-ray cholangiography has a high sensitivity and specificity of detecting bile duct stones and is the gold standard. There are no studies describing the sensitivity and specificity of IFC for bile duct stone detection.

Research question. What is the sensitivity of IFC to visualize bile duct stones? Method. Prospective study with 40 patients undergoing planned laparoscopic cholecystectomy with preoperative magnetic resonance cholangiopancreatography (MRCP) (gold standard) and intraoperative IFC, X-ray cholangiography and choledochuscopy in that order.

Primary outcome. Sensitivity of visualization of bile duct stone by fluorescent cholangiography and secondary outcome is visualization of anatomy.

Detailed Description

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Conditions

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Gall Stones, Common Bile Duct

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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MRCP positive

Group Type EXPERIMENTAL

Presence of bile duct stones

Intervention Type DIAGNOSTIC_TEST

MRCP verified gall stones in the bile ducts

MRCP negative

Group Type ACTIVE_COMPARATOR

Non-presence of bile duct stones

Intervention Type DIAGNOSTIC_TEST

MRCP without bile duct stones

Interventions

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Presence of bile duct stones

MRCP verified gall stones in the bile ducts

Intervention Type DIAGNOSTIC_TEST

Non-presence of bile duct stones

MRCP without bile duct stones

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients suspected of having bile duct stones by either blood samples, MRCP or medical history (see definitions)
* Patient age ≥ 18 years
* Preoperative MRCP
* Operation performed by a project surgeon

Exclusion Criteria

* Open cholecystectomy (including conversion from laparoscopic to open)
* Acute cholecytitis or cholangitis
* Pancreatitis
* Iodine or indocyanine green allergy
* Liver or renal insufficiency
* Thyrotoxicosis
* Cholecystectomy not the primary surgical procedure
* Pregnancy or lactation
* Legally incompetent for any reason
* Withdrawal of inclusion consent at any time
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hvidovre University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Lars Lang Lehrskov

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lars L Lehrskov, MD

Role: PRINCIPAL_INVESTIGATOR

Hvidovre University Hospital

Locations

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Hvidovre University Hospital

Holte, Danmark, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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IFC4

Identifier Type: -

Identifier Source: org_study_id

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