Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2023-10-06
2025-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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All participants
All participants will complete all experimental conditions, which include transcranial magnetic stimulation (continuous theta-burst stimulation) to a brain region of experimental interest and to a control brain region.
Transcranial magnetic stimulation
Transcranial magnetic stimulation will be used to stimulate brain activity in a brain region of experimental interest (lateral parietal cortex) and in a control brain region (vertex). All participants will experience both forms of stimulation, in separate sessions. Stimulation will be applied as a probe to understand the basic phenomenon of how brain processes support episodic memory.
Interventions
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Transcranial magnetic stimulation
Transcranial magnetic stimulation will be used to stimulate brain activity in a brain region of experimental interest (lateral parietal cortex) and in a control brain region (vertex). All participants will experience both forms of stimulation, in separate sessions. Stimulation will be applied as a probe to understand the basic phenomenon of how brain processes support episodic memory.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Fluent in English
* Free of major neurological or psychiatric illness
* Right-handed
* Normal or corrected to normal vision
Exclusion Criteria
* History of a learning disorder (e.g., attention deficit disorder, dyslexia)
* History of neurological disorder or brain injury, including family history of epilepsy, convulsions or seizures, stroke; vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication, and any unexplained lifetime loss of consciousness/syncope
* Use of medications that reduce seizure threshold (e.g., tricyclic antidepressants, neuroleptic agents)
* History of neurosurgery
* History of heart disease
* Recreational drug use in the past two months
* Uncontrollable shaking, or inability to sit/lie still for one hour
* Evidence of neurological disorders or structural abnormalities, based on MRI
* Pregnancy
* Prior surgeries, conditions, and/or implants that are not MRI-safe, including: pacemaker, pacemaker wires, artificial heart valve, brain aneurysm surgery, middle ear implant, non-removable hearing aids, braces, or extensive dental work, implanted mechanical or electrical device, artificial limb or joint
* Foreign metallic objects in the body, such as bullets, BBs, shrapnel, or metalwork fragments
* History of metal work or ocular metallic foreign bodies
* History of uncontrolled migraines or susceptibility to headaches
* Use of centrally-acting medications and drugs, with the exception of caffeine, within the last 12 hours
* Concurrent treatment with ototoxic medications
* Current sleep deprivation, extreme fatigue, or recent jet lag
* Claustrophobia
* Pre-existing noise induced hearing loss
* Any prior adverse experience (e.g. physical or psychological discomfort) with repetitive TMS or MRI scanning
18 Years
35 Years
ALL
Yes
Sponsors
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Boston College
OTHER
Responsible Party
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Locations
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Boston College
Chestnut Hill, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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