Functional MRI Study of Attention in Normal Controls and Traumatic Brain Injured Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2003-10-31

Study Completion Date

2003-10-31

Brief Summary

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The purpose of this study will be to assess the attentional ability of patients with mild to moderate traumatic brain injury (TBI) using the functional Magnetic Resonance Imaging (fMRI) technique. Methodology for specific aim 1: sagittal pilot scan, 3-D anatomical MRI, Whole brain echo-planar imaging (EPI), and functional MRI techniques with traumatic brain injured subjects doing a Continuous Performance Test (CPT) attention task and compare the pattern of activation with those of normal controls to see if there is a failure to activate frontal lobes in the traumatic brain injured subjects.

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Detailed Description

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Conditions

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Mild Traumatic Brain Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Mild Traumatic Brain Injury group

functional magnetic resonance imaging fMRI

Intervention Type OTHER

functional magnetic resonance imaging fMRI

2

Normal healthy control group

functional magnetic resonance imaging fMRI

Intervention Type OTHER

functional magnetic resonance imaging fMRI

Interventions

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functional magnetic resonance imaging fMRI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Mild to moderate brain injury patients referred to the UCI Brain Imaging Center.

* Mild brain injury patients will be defined as having a Glascow Coma Scale (GCS) scale of 13-15.
* Moderate brain injury brain injury patients will be defined as having a Glascow Coma Scale (GCS) scale of 9-12 .
* Normal healthy control subjects (20)

Exclusion Criteria

* Pre-accident neuropathology, psychopathology, or secondary neuropathological complications, or chemical abuse
* Patients who required intracranial surgical intervention
* Children, pregnant women, or institutionalized individuals unable to freely give consent
* Patients with implanted surgical clips (hemostatic clips) or other ferromagnetic material
* Patients engaged in occupations or activities which may cause accidental lodging of ferromagnetic materials, or who may have imbedded metal fragments from military activities
* Patients with permanent (tattoo) eye-liner or with facial make-up (severe eye irritation has been reported)
* Patients with metallic implants, because they may cause artifacts in diagnostic images due to magnetic field distortion
* Patients with implanted prosthetic heart valves
* Patients with pacemakers, neuro-stimulation devices
* Subjects who have severe claustrophobia.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes