Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
108 participants
OBSERVATIONAL
2005-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Cocaine dependent
No interventions assigned to this group
Opioid dependent
No interventions assigned to this group
Alcohol dependent
No interventions assigned to this group
Healthy controls
No interventions assigned to this group
Adolescents
No interventions assigned to this group
Pathological gamblers
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Able to read and write.
* COCAINE DEPENDENT SUBJECTS: meet DSM-IV criteria for cocaine dependence; report current cocaine use of at least once a week or more; confirmation of cocaine use via positive urine toxicology screen during initial assessments and upon admission to the CNRU.
* OPIOID DEPENDENT SUBJECTS: meet DSM-IV criteria for opiate dependence and are participating in substance abuse treatment including pharmacotherapy for opioid dependence.
* ALCOHOL DEPENDENT SUBJECTS: meet DSM-IV criteria for alcohol dependence and are currently abstinent from alcohol as documented by substance abuse treatment participation.
* HEALTHY CONTROLS: negative urine toxicology screens during intake appointments indicating no history of current or past dependence on alcohol or illicit drug use.
* Healthy adolescent boys and girls, with no medical or psychiatric conditions;
* WOMEN: have a regular menstrual cycle.
Exclusion Criteria
* Regular use of any psychoactive drugs including anxiolytics and antidepressants.
* Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, liver, thyroid pathology; subjects on medications for any medical condition will be excluded.
* Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded including subjects who work as welders.
* Women on oral contraceptives, peri- and post-menopausal women, and pregnant or lactating women (as alterations in stress response are associated with these states).
* IQ below 75
13 Years
50 Years
ALL
Yes
Sponsors
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National Institutes of Health (NIH)
NIH
National Institute on Drug Abuse (NIDA)
NIH
Yale University
OTHER
Responsible Party
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Rajita Sinha
Professor
Principal Investigators
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Rajita Sinha, PhD
Role: PRINCIPAL_INVESTIGATOR
Yale University
Locations
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Yale Stress Center
New Haven, Connecticut, United States
Countries
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Other Identifiers
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0405026787
Identifier Type: -
Identifier Source: org_study_id