Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence
NCT ID: NCT02557815
Last Updated: 2015-09-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
80 participants
INTERVENTIONAL
2012-02-29
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SINGLE
Study Groups
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Active Repetitive Transcranial Magnetic Stimulation (rTMS)
Repetitive Transcranial Magnetic Stimulation: Active 10hz stimulation over the right dorsolateral Prefrontal Cortex (dlPFC)
Repetitive Transcranial Magnetic Stimulation
Repetitive 10Hz right DLPFC stimulation using Magstim TMS apparatus
Sham stimulation
Repetitive Transcranial Magnetic Stimulation: sham stimulation over the right dlPFC
Repetitive Transcranial Magnetic Stimulation
Repetitive 10Hz right DLPFC stimulation using Magstim TMS apparatus
Interventions
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Repetitive Transcranial Magnetic Stimulation
Repetitive 10Hz right DLPFC stimulation using Magstim TMS apparatus
Eligibility Criteria
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Inclusion Criteria
* Currently abstinent
Exclusion Criteria
* not eligible for MRI (metals or claustrophobia)
* (familial) history of epilepsy
* current psychiatric disorders (besides alcohol dependence)
21 Years
60 Years
ALL
Yes
Sponsors
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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER
Responsible Party
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Anneke E. Goudriaan
Prof. Dr.
Principal Investigators
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Anneke E Goudriaan, Prof dr.
Role: PRINCIPAL_INVESTIGATOR
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
References
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Jansen JM, van Holst RJ, van den Brink W, Veltman DJ, Caan MW, Goudriaan AE. Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls. Addict Biol. 2015 Sep;20(5):979-89. doi: 10.1111/adb.12199. Epub 2014 Dec 5.
Jansen JM, Daams JG, Koeter MW, Veltman DJ, van den Brink W, Goudriaan AE. Effects of non-invasive neurostimulation on craving: a meta-analysis. Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2472-80. doi: 10.1016/j.neubiorev.2013.07.009. Epub 2013 Jul 31.
Jansen JM, van den Heuvel OA, van der Werf YD, de Wit SJ, Veltman DJ, van den Brink W, Goudriaan AE. The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing, Reappraisal, and Craving in Alcohol Use Disorder Patients and Healthy Controls: A Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2019 May 7;10:272. doi: 10.3389/fpsyt.2019.00272. eCollection 2019.
Jansen JM, van den Heuvel OA, van der Werf YD, de Wit SJ, Veltman DJ, van den Brink W, Goudriaan AE. Emotion Processing, Reappraisal, and Craving in Alcohol Dependence: A Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2019 Apr 9;10:227. doi: 10.3389/fpsyt.2019.00227. eCollection 2019.
Other Identifiers
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91713354
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
EA1027
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
EA1027
Identifier Type: -
Identifier Source: org_study_id
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