Plasticity of the Compassionate Brain

NCT ID: NCT01833104

Last Updated: 2016-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

332 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2016-02-29

Brief Summary

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The purpose of the study is to look at the long term effects of a complex socio-affective mental training program on a neuroscientific-, hormonal-, behavioral-, biological, and subjective measures-level. The training protocol consists of a variety of meditation and other mental health techniques, which are trained over the period of 3-9 months (13 weeks per Module; 1-3 Modules)

Detailed Description

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The ReSource Project is a unique, large-scale study on the effects of mental training techniques. Over a period of three to nine months, participants practice a wide range of mental exercises that are designed to enhance attentional control, body- and self-awareness, emotion regulation, self-care, compassion, empathy, and perspective taking. Overall, the aim of the training is to improve mental health and social skills. It may reduce stress, improve mental clarity, increase life satisfaction, and lead to a better understanding of others' views, values, and actions.

The ReSource Project is a secular program developed by a team of experienced meditation teachers, scientists, and psychotherapists.

Over the last decades, isolation, stress, and psychological tensions have been steadily increasing in our society. Mental training can alter stress responses, physical health, resilience, attention, perception, emotional experience, and social behavior. Evidence for these results is based on previous studies showing behavioral changes, as well as observed changes in brain function and structure. Moreover, health factors, such as peripheral autonomic responses, stress hormones, and immune parameters were significantly changed after training.

The ReSource Project consists of three consecutive modules: called "Presence", "Perspective", and "Affect". The Presence Module trains mindful attention to internal mental and physical processes. The Perspective Module focuses on socio-cognitive abilities, such as insight into the nature of the mind and self, and also the ability to assume the perspective of others. The Affect Module focuses on constructive ways of dealing with difficult emotions, and works to cultivate prosocial motivations and positive emotions such as compassion.

In contrast to most previous studies of just a few months, the ReSource Project will be conducted over a period of 3-9 months for three experimental cohorts (cohorts start in a shifted design; 2 cohorts train over a period of 9 months (all 3 Modules in different orders, 13 weeks per Module), 1 cohort trains over 3 months (only the Affect Module)), and will cover a wide range of practices intended to enhance cognitive and socio-affective skills. 2 retest control cohorts account for the effects of repeated testing.

Conditions

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Healthy Subjects

Keywords

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Healthy subjects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Training Cohort 1 (TC1)

(N = 80) in the order "Presence - Affect - Perspective"

Group Type EXPERIMENTAL

Presence - Affect - Perspective.

Intervention Type BEHAVIORAL

As specified above however the order is interchanged between the cohorts TC1 and TC2.

Training Cohort 2 (TC2)

(N = 81) in the order "Presence - Perspective - Affect"

Group Type EXPERIMENTAL

Presence - Perspective - Affect

Intervention Type BEHAVIORAL

PRESENCE: Cultivate attentional skills \& interoceptive body awareness. 2 exercises: "Breathing Meditation" \& "Body Scan".

PERSPECTIVE: Focus on cognitive aspects of compassion; take perspectives on thoughts, the self, \& other people; observe more macroscopic dynamics within oneself, your inner "parts"; do not fully identify with them / be aware of their transiency; strengthen the ability to detach from one's own perspective, take the perspectives of others, trying to understand their thoughts, motives, feelings. 2 exercises: "Observing-thoughts Meditation" \& "Perspective Dyad".

AFFECT: Cultivate emotional/motivational aspects of compassion; cultivate a sense of benevolence, love, care, "opening the heart" for oneself and others; work with obstacles, e.g. fear, anger or sadness ("emotion acceptance"); pro-social motivations as an alley towards loving / benevolent feelings and as a consequence of them. 2 exercises: "Loving-kindness Meditation" \& "Affect Dyad".

Retest Control Cohort 1 (RCC1)

(up to N = 30) this is a non-intervention control group to access measurement effects and will be tested at each timepoint.

Group Type NO_INTERVENTION

No interventions assigned to this group

Training Cohort 3 (TC3)

(N = 81) here, the "Affect Module" only intervention is administered.

Group Type ACTIVE_COMPARATOR

Affect

Intervention Type BEHAVIORAL

AFFECT: Cultivate emotional/motivational aspects of compassion; cultivate a sense of benevolence, love, care, "opening the heart" for oneself and others; work with obstacles, e.g. fear, anger or sadness ("emotion acceptance"); pro-social motivations as an alley towards loving / benevolent feelings and as a consequence of them. 2 exercises: "Loving-kindness Meditation" \& "Affect Dyad".

Retest Control Cohort 2 (RCC2)

(up to N = 60) this is a non-intervention control group to access measurement effects and will be tested at each timepoint.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Presence - Perspective - Affect

PRESENCE: Cultivate attentional skills \& interoceptive body awareness. 2 exercises: "Breathing Meditation" \& "Body Scan".

PERSPECTIVE: Focus on cognitive aspects of compassion; take perspectives on thoughts, the self, \& other people; observe more macroscopic dynamics within oneself, your inner "parts"; do not fully identify with them / be aware of their transiency; strengthen the ability to detach from one's own perspective, take the perspectives of others, trying to understand their thoughts, motives, feelings. 2 exercises: "Observing-thoughts Meditation" \& "Perspective Dyad".

AFFECT: Cultivate emotional/motivational aspects of compassion; cultivate a sense of benevolence, love, care, "opening the heart" for oneself and others; work with obstacles, e.g. fear, anger or sadness ("emotion acceptance"); pro-social motivations as an alley towards loving / benevolent feelings and as a consequence of them. 2 exercises: "Loving-kindness Meditation" \& "Affect Dyad".

Intervention Type BEHAVIORAL

Presence - Affect - Perspective.

As specified above however the order is interchanged between the cohorts TC1 and TC2.

Intervention Type BEHAVIORAL

Affect

AFFECT: Cultivate emotional/motivational aspects of compassion; cultivate a sense of benevolence, love, care, "opening the heart" for oneself and others; work with obstacles, e.g. fear, anger or sadness ("emotion acceptance"); pro-social motivations as an alley towards loving / benevolent feelings and as a consequence of them. 2 exercises: "Loving-kindness Meditation" \& "Affect Dyad".

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* is a healthy, normal subject

Exclusion Criteria

* can not participate in the kick-off retreats
* does not have a PC with internet connection at home
* does not speak and understand German fluently
* has studied or is studying Psychology/Psychotherapy
* has a daily meditation practice
* attended a meditation retreat within the last 2 years
* exceeds normal BDI
* not able to lie still in MRT scanner for scanning duration
* is pregnant or in lactation or plans to become pregnant
* has had a larger surgery or plans to have one during the next year
* has metal parts in the body (due to MRT scanning)
* has a cardiac pacemaker
* carries an insulin or medicine pump
* carries a shunt
* has a heart valve
* has an inner ear implant
* carries metal, piercings or electronics on / in the body, that cannot be removed
* has a tattoo in the head / throat area
* works in the field of metal processing (if that leads to small metal parts on the body, that cannot be removed)
* has dyslexia or ametropia
* has claustrophobia (MRI scanner)
* has severe hearing problems (MRI scanner)
* has limitations with motor functions
* has or had a severe injury in the head area
* has or had a neurological disease (meningitis, cerebral hemorrhage, cerebral infarct, brain trauma, coma etc.)
* has or had epilepsy
* has a severe disease targeting the musculoskeletal system
* has a heart disease
* has a (peripheral) vascular disease, circulatory disorder, Raynaud´s disease
* has a liver disease
* has a respiratory disease
* has an affected kidney
* has an advanced multiple sclerosis
* has an infection (e.g., HIV)
* is in treatment due to chronic pain
* is on medication that effects the central nervous system (psychotropic drugs) during the last three months
* has been diagnosed with a mental health disease and is in treatment at the moment or within the last 2 years
* reaches clinical scores in the following questionnaires: TAS-20, MDI, STAI-trait, PHQ;
* reaches clinical scores following DSM-IV as determined by a SCID I and SCID II clinical interview
Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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European Research Council

OTHER

Sponsor Role collaborator

Max Planck Institute for Human Cognitive and Brain Sciences

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tania Singer, Prof. Dr.

Role: STUDY_CHAIR

Max Planck Institute for Human Cognitive and Brain Sciences

Locations

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Max Planck Institute for Human Cognitive and Brain Sciences

Leipzig, Saxony, Germany

Site Status

Max Planck Institute, Humboldt University, Campus Nord, Haus 5

Berlin, State of Berlin, Germany

Site Status

Countries

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Germany

References

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Bockler A, Singer T. Longitudinal evidence for differential plasticity of cognitive functions: Mindfulness-based mental training enhances working memory, but not perceptual discrimination, response inhibition, and metacognition. J Exp Psychol Gen. 2022 Jul;151(7):1573-1590. doi: 10.1037/xge0001143. Epub 2021 Nov 29.

Reference Type DERIVED
PMID: 34843370 (View on PubMed)

Puhlmann LMC, Vrticka P, Linz R, Stalder T, Kirschbaum C, Engert V, Singer T. Contemplative Mental Training Reduces Hair Glucocorticoid Levels in a Randomized Clinical Trial. Psychosom Med. 2021 Oct 1;83(8):894-905. doi: 10.1097/PSY.0000000000000970.

Reference Type DERIVED
PMID: 34259441 (View on PubMed)

Puhlmann LMC, Valk SL, Engert V, Bernhardt BC, Lin J, Epel ES, Vrticka P, Singer T. Association of Short-term Change in Leukocyte Telomere Length With Cortical Thickness and Outcomes of Mental Training Among Healthy Adults: A Randomized Clinical Trial. JAMA Netw Open. 2019 Sep 4;2(9):e199687. doi: 10.1001/jamanetworkopen.2019.9687.

Reference Type DERIVED
PMID: 31553468 (View on PubMed)

Hildebrandt LK, McCall C, Singer T. Socioaffective versus sociocognitive mental trainings differentially affect emotion regulation strategies. Emotion. 2019 Dec;19(8):1329-1342. doi: 10.1037/emo0000518. Epub 2018 Dec 27.

Reference Type DERIVED
PMID: 30589299 (View on PubMed)

Kok BE, Singer T. Effects of Contemplative Dyads on Engagement and Perceived Social Connectedness Over 9 Months of Mental Training: A Randomized Clinical Trial. JAMA Psychiatry. 2017 Feb 1;74(2):126-134. doi: 10.1001/jamapsychiatry.2016.3360.

Reference Type DERIVED
PMID: 28030741 (View on PubMed)

Related Links

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http://www.resource-project.org

Homepage of the ReSource Project Webpage

Other Identifiers

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ReSource

Identifier Type: -

Identifier Source: org_study_id