Drugs Brain and Behavior (DDP)

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

138 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-01

Study Completion Date

2024-06-01

Brief Summary

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In this project, we will examine individual differences in the effects of a stimulant drug, methamphetamine (MA), on mesolimbic reward function using fMRI.

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Detailed Description

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Conditions

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Stimulant Use

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo Then Methamphetamine

Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive 20 mg methamphetamine.

Group Type EXPERIMENTAL

Methamphetamine

Intervention Type DRUG

Participants will be given 20 mg of Methamphetamine.

placebo oral tablet

Intervention Type DRUG

Participants will be given a placebo capsule that will only contain lactose.

MethamphetamineThen Placebo

Participants first receive 20 mg methamphetamine at their first session in the laboratory Then will return to the laboratory 72 hours later and will receive placebo.

Group Type EXPERIMENTAL

Methamphetamine

Intervention Type DRUG

Participants will be given 20 mg of Methamphetamine.

placebo oral tablet

Intervention Type DRUG

Participants will be given a placebo capsule that will only contain lactose.

Interventions

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Methamphetamine

Participants will be given 20 mg of Methamphetamine.

Intervention Type DRUG

placebo oral tablet

Participants will be given a placebo capsule that will only contain lactose.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* BMI between 19 and 26
* Right Handed
* Less than 4 alcohol or caffeinated beverages a day.

Exclusion Criteria

* High blood pressure
* Any medical condition requiring regular medication
* Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis
* Individuals with a history of dependence on stimulant drugs
* Women who are pregnant or trying to become pregnant.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes