Brain Mechanisms of Reducing Polysubstance Use

NCT ID: NCT06324786

Last Updated: 2025-04-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-01

Study Completion Date

2026-08-31

Brief Summary

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The proposed study will test whether neurofeedback (NF) could optimize integrative body-mind training (IBMT) practice.

Detailed Description

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The proposed study will test whether real-time NF could optimize IBMT practice and improve effects in reducing polysubstance use through targeting self-control networks in the brain.

Conditions

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Multiple Drug Use

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

mindfulness or/and active/sham neurofeedback
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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IBMT

An evidence-based preventive intervention - integrative body-mind training (IBMT) has shown positive effects in reducing stress and improving self-control and brain plasticity. It has bodifulness and mindfulness components.

Group Type EXPERIMENTAL

IBMT

Intervention Type BEHAVIORAL

IBMT is an effortless mindfulness technique

NF

An evidence-based intervention - NF can not only provide real-time feedback for practice but also target the self-control networks, suggesting the possibility of augmenting IBMT effects via NF.

Group Type EXPERIMENTAL

NF

Intervention Type BEHAVIORAL

NF is a mental training technique.

IBMT + NF

The combined IBMT and NF also show positive effects in reducing substance use.

Group Type EXPERIMENTAL

IBMT

Intervention Type BEHAVIORAL

IBMT is an effortless mindfulness technique

NF

Intervention Type BEHAVIORAL

NF is a mental training technique.

Sham NF

Sham NF has the same settings as the active NF but does not have correct parameters of stimulation.

Group Type SHAM_COMPARATOR

NF

Intervention Type BEHAVIORAL

NF is a mental training technique.

Interventions

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IBMT

IBMT is an effortless mindfulness technique

Intervention Type BEHAVIORAL

NF

NF is a mental training technique.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* At least 18 years old
* Free of any psychiatric diagnoses or medication (besides a substance use disorder (SUD) to alcohol, tobacco, or cannabis)
* In the past month, at least 4 episodes of heavy episodic drinking; at least 3 occasions of cannabis use; and daily cigarette use for at least the past month
* Normal or corrected-to-normal vision
* Written informed consent
* No previous meditation or NF experiences

Exclusion Criteria

* Any psychiatric diagnoses other than an SUD
* Medical disorder(s) that may affect the central nervous system; medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females)
* Excluding cannabis, evidence of recent (past month) illicit drug use
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Arizona State University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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YiYuan Tang

Phoenix, Arizona, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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YiYuan Tang

Role: CONTACT

4807903577

Facility Contacts

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YiYuan Tang

Role: primary

480-790-3577

Other Identifiers

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2024 IBMT NF

Identifier Type: -

Identifier Source: org_study_id

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