Neurofeedback Removal of Emotional Information From Mind

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-30

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This project will examine whether individuals can be trained, using real-time feedback about brain function during neuroimaging, to effectively remove thoughts from mind by providing them with a sense of what it feels like to successfully remove a thought.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4

NCT06563310

Anxiety Social Anxiety Disorder Panic Disorder +1 more

RECRUITING NA

Neurofeedback Enhanced Cognitive Reappraisal Training

NCT06132659

Anxiety Social Anxiety Disorder Panic Disorder +1 more

COMPLETED NA

Targeting Large-scale Networks in Depression With Real-time fMRI (Functional Magnetic Resonance Imaging) Neurofeedback

NCT05934604

Healthy Participants

COMPLETED NA

Cognitive Process-based Real-time fMRI Neurofeedback in MDD and Rumination

NCT04941066

Depression Anxiety

COMPLETED NA

Neurofeedback in Clinical High Risk

NCT06492343

Real Neurofeedback From DMN Sham Neurofeedback From Motor Cortex

NOT_YET_RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

On the first day, an anatomical MRI scan will be followed by a 12-min resting state scan, a 30-min item localizer task in which participants view a set of 80 scene stimuli 3 times each, and a 10-min memory test outside the scanner. The brain data from the localizer will be used to identify baseline measures of item-specific brain activity patterns. On 3 subsequent days (within the next 2 weeks), participants will receive neurofeedback training. In each 1-hr session, an anatomical scan will be followed by 8 runs (5 min each) of 20 trials, half with each operation, randomly ordered, and a 10-min behavioral memory test. In the scanner, participants will perform a working memory task in which they encode a scene image and then are instructed to either maintain that image in mind for a few seconds or to suppress that image from mind. At the end of each trial, neurofeedback will be provided to the participant visually to denote their "level of engagement" in the instructed operation on that trial. The neurofeedback is derived from the MRI classifier fit for the instructed operation (maintain or suppress) from a working memory operation classifier that is pre-trained on prior data. Participants (N=40) will be randomly assigned to either the positive or negative valence condition. They will encounter stimuli from their assigned valence only during the neuroimaging task, but from both valences during the behavioral tests, so that the investigators can evaluate whether any learning generalizes across emotional valence.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neurofeedback Cognitive Training Memory, Short-Term Functional Magnetic Resonance Imaging (fMRI)

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants will be randomly assigned to either the positive or negative valence condition. They will encounter stimuli from their assigned valence only during the fMRI task, but from both valences during the behavioral tests, so that the investigators can evaluate whether any learning generalizes across emotional valence.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Positive stimuli neurofeedback

Participants will encounter only positive stimuli during the fMRI task but will be tested on both positive and negative valence stimuli during the behavioral memory tests.

Group Type EXPERIMENTAL

fMRI neurofeedback

Intervention Type OTHER

fMRI neurofeedback is a technique that allows individuals to observe real-time feedback of their brain activity as measured by fMRI scans. During a session, the participant lies inside an MRI scanner while their whole brain is scanned. This data is processed in real-time by a computer and then presented to the participant in the form of visual feedback. This feedback might be presented as a graph, a color-coded representation, or some other easily interpretable format. The participant is instructed to modulate their brain activity based on the feedback they receive. This can involve various mental strategies, such as focusing attention on specific thoughts, images, or sensations. Over repeated sessions, participants learn to consciously influence their brain activity based on the feedback they receive. Through trial and error, they discover which mental strategies are most effective for achieving their desired changes in brain activity.

Negative stimuli neurofeedback

Participants will encounter only negative stimuli during the fMRI task but will be tested on both positive and negative valence stimuli during the behavioral memory tests.

Group Type EXPERIMENTAL

fMRI neurofeedback

Intervention Type OTHER

fMRI neurofeedback is a technique that allows individuals to observe real-time feedback of their brain activity as measured by fMRI scans. During a session, the participant lies inside an MRI scanner while their whole brain is scanned. This data is processed in real-time by a computer and then presented to the participant in the form of visual feedback. This feedback might be presented as a graph, a color-coded representation, or some other easily interpretable format. The participant is instructed to modulate their brain activity based on the feedback they receive. This can involve various mental strategies, such as focusing attention on specific thoughts, images, or sensations. Over repeated sessions, participants learn to consciously influence their brain activity based on the feedback they receive. Through trial and error, they discover which mental strategies are most effective for achieving their desired changes in brain activity.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

fMRI neurofeedback

fMRI neurofeedback is a technique that allows individuals to observe real-time feedback of their brain activity as measured by fMRI scans. During a session, the participant lies inside an MRI scanner while their whole brain is scanned. This data is processed in real-time by a computer and then presented to the participant in the form of visual feedback. This feedback might be presented as a graph, a color-coded representation, or some other easily interpretable format. The participant is instructed to modulate their brain activity based on the feedback they receive. This can involve various mental strategies, such as focusing attention on specific thoughts, images, or sensations. Over repeated sessions, participants learn to consciously influence their brain activity based on the feedback they receive. Through trial and error, they discover which mental strategies are most effective for achieving their desired changes in brain activity.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Right-handed
* Speak English fluently
* Minimum 8th grade education
* Good hearing
* Good vision or minimal correction with contacts or eyeglasses

Exclusion Criteria

* History of significant illnesses (including cardiovascular disease, cancer, immunodeficiency disorders (including HIV infection)
* Diabetes
* Unstable endocrine disorders
* Neurological disorders
* Neuromuscular disorders
* Blood dyscrasias
* History of major psychiatric disorders (including schizophrenia, bipolar disorder, and dementia)
* Substance dependence
* History of head trauma with loss of consciousness
* Cerebrovascular accident
* Seizures
* Neurosurgical intervention
* Metal implants in the body (including pacemakers, neurostimulators, or other metal objects)
* Metal piercings that cannot be removed for the scan
* Women who are pregnant or who think they may be pregnant

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes