Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2023-03-01
2025-02-28
Brief Summary
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Detailed Description
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All subjects will be scanned, and each will complete the same behavioral intervention. First, the investigators will aim to assess the reliability of this hybrid imaging technique by having subjects complete two identical scan sessions. Second, the investigators will deliver a behavioral intervention to test the relationship between stimuli predictability, CMRglc, CMRO2, and OGI.
This experimental design is capable of producing effects observable in single subjects, and prior studies using fPET and dual-calibrated fMRI have produced effect sizes that our sample size is more than adequate to detect.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Behavioral intervention
Subjects are presented with a simultaneous sequence of faces and spoken words. Face stimuli include a representative sample of realistic faces across a range of ages. Spoken word stimuli are simple nouns spoken by a single female speaker.
(Un)predictable and (un)attended stimuli
Subjects will complete four task conditions in each scan session: (1) Visual Unpredictable, (2) Visual Predictable, (3) Auditory Unpredictable, and (4) Auditory Predictable. In visual and auditory conditions subjects attend to visual or auditory stimuli and ignore the other domain, pressing a button when they detect an infrequently occurring stimulus inversion in the target domain. In unpredictable and predictable conditions, the attended domain either presents random (unpredictable) stimuli, or the same face or word stimuli repeated (predictable).
Interventions
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(Un)predictable and (un)attended stimuli
Subjects will complete four task conditions in each scan session: (1) Visual Unpredictable, (2) Visual Predictable, (3) Auditory Unpredictable, and (4) Auditory Predictable. In visual and auditory conditions subjects attend to visual or auditory stimuli and ignore the other domain, pressing a button when they detect an infrequently occurring stimulus inversion in the target domain. In unpredictable and predictable conditions, the attended domain either presents random (unpredictable) stimuli, or the same face or word stimuli repeated (predictable).
Eligibility Criteria
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Inclusion Criteria
* No contraindications to MRI or PET scanning.
* Right-handed.
* Fluent to speak, read, and understand English.
Exclusion Criteria
* Contraindications to fMRI scanning and PET scanning (including the presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia)
* Inability to lie motionless in the scanner
* Pregnancy, seeking or suspecting pregnancy, or breastfeeding
* History of major head trauma
* Intracranial lesion
* Cardiovascular disorders, including heart disorders or high blood pressure \[\>155/95\]
* Breathing problems such as severe asthma, emphysema, or pulmonary disease
* Bleeding disorder, or use of anticoagulants
* Bladder obstruction, urinary problems, or history of impaired elimination
* Known kidney or liver problems
* Past severe COVID-19 infection
* Intestinal blockage
* Raynaud syndrome
* Anemia
* Peripheral nerve injury
* Diabetes
* Glaucoma
* Current or recent use of medications (neurological or psychiatric) affecting brain function
* Current or past history of major medical, neurological, or psychiatric condition
* Current or past history of chronic pain (assessed at the discretion of PI)
* Current smoker
* Body mass index above 35
* Research-related radiation exposure exceeds current Radiology Department guidelines
* Lack of current health insurance coverage
* Employed under the direct supervision of the investigators conducting the research
* Unwilling or unable to cooperate with breathing maneuvers required during the gas challenge
* Respiratory or cardiac limitations to breathing at 20 L/min
21 Years
35 Years
ALL
Yes
Sponsors
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Massachusetts General Hospital
OTHER
Responsible Party
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Christin Y. Sander, PhD
Assistant Professor
Principal Investigators
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Christin Y Sander, PhD
Role: PRINCIPAL_INVESTIGATOR
Athinoula A. Martinos Center for Biomedical Imaging
Locations
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Athinoula A. Martinos Center for Biomedical Imaging
Charlestown, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2022P002851
Identifier Type: -
Identifier Source: org_study_id
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