fMRI of Hypothalamic Responses to Taste, Temperature and Glucose
NCT ID: NCT03202342
Last Updated: 2017-06-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
16 participants
INTERVENTIONAL
2013-11-11
2014-10-30
Brief Summary
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Detailed Description
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In order to investigate the role of hypothalamic neural activity in response to taste, glucose and temperature, fMRI will be performed before, during and after ingestion of 300 ml plain water or water with added ethyl butyrate (pineapple flavour), added glucose or added ethyl butyrate plus glucose. All beverages will be consumed at 22 °C and the combination will also be drunk at 0 °C.
The study uses a randomised cross-over design in 16 healthy male subjects with a normal body weight. There will be an interval of at least one week between the five occasions.
BOLD signal intensity of the hypothalamus will be continuously measured for 21 minutes (5 minutes baseline, 4 minutes during drinking and 12 minutes after drinking).
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Water/gluc/gluc+EB/EB/gluc+EB_cold
First Water 22 C, then Glucose 22 C, then Glucose + Ethyl butyrate 22 C, then Ethyl butyrate 22 C and then Glucose + Ethyl butyrate 0 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Water/gluc+EB/gluc/gluc+EB_cold/EB
First Water 22 C, then Glucose + Ethyl butyrate 22 C, then Glucose 22 C, then Glucose + Ethyl butyrate 0 C and then Ethyl butyrate 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Gluc/water/EB/gluc+EB/glucose+EB_cold
First Glucose 22 C, then Water 22 C, then Ethyl butyrate 22 C, then Glucose + Ethyl butyrate 22 C and then Glucose + Ethyl butyrate 0 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Gluc/EB/water/gluc+EB_cold/gluc+EB
First Glucose 22 C, then Ethyl butyrate 22 C, then Water 22 C, then Glucose + Ethyl butyrate 0 C and then Glucose + Ethyl butyrate 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
EB/Gluc/gluc+EB_cold/water/glucose+EB
First Ethyl butyrate 22 C, then Glucose 22 C, then Glucose + Ethyl butyrate 0 C, then Water 22 C and then Glucose + Ethyl butyrate 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
EB/gluc+EB_cold/gluc/glucose+EB/water
First Ethyl butyrate 22 C, then Glucose + Ethyl butyrate 0 C, then Glucose 22 C, then Glucose + Ethyl butyrate 22 C and then Water 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Gluc+EB_cold/water/glucose+EB/glucose/EB
First Glucose + Ethyl butyrate 22 C, then Water 22 C, then Glucose + Ethyl butyrate 0 C, then Glucose 22 C and then Ethyl butyrate 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Gluc+EB_cold/glucose+EB/water/EB/glucose
First Glucose + Ethyl butyrate 22 C, then Glucose + Ethyl butyrate 0 C, then Water 22 C, then Ethyl butyrate 22 C and then Glucose 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Gluc+EB_cold/gluc+EB/EB/water/glucose
First Glucose + Ethyl butyrate 0 C, then Glucose + Ethyl butyrate 22 C, then Ethyl butyrate 22 C, then Water 22 C and then Glucose 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Gluc+EB_cold/EB/gluc+EB/glucose/water
First Glucose + Ethyl butyrate 0 C, then Ethyl butyrate 22 C, then Glucose + Ethyl butyrate 22 C, then Glucose 22 C and then Water 22 C
Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Interventions
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Water
Water, 300 ml, at room temperature
Glucose
Water containing 50 g glucose, 300 ml, at room temperature
Ethyl butyrate
Water containing ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at room temperature
Glucose + ethyl butyrate 0 C
Water containing 50 g glucose and ethyl butyrate (pineapple flavour) 300 ml, at 0 degrees centigrade
Eligibility Criteria
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Inclusion Criteria
* Age between 18 and 25 years
* BMI between 20 and 23 kg/m2
* Length between 170 and 190 centimetres
Exclusion Criteria
* Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain
* Any significant chronic disease
* Renal or hepatic disease
* Recent weight changes or attempts to lose weight (\> 3 kg weight gain or loss, within the last 3 months)
* Smoking (current or last 6 months)
* Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year
* Recent blood donation (within the last 2 months)
* Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year
* Contra-indication to MRI scanning:
* Claustrophobia
* Pacemakers and defibrillators
* Nerve stimulators
* Intracranial clips
* Intraorbital or intraocular metallic fragments
* Cochlear implants
* Ferromagnetic implants
18 Years
25 Years
MALE
Yes
Sponsors
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Leiden University Medical Center
OTHER
Unilever R&D
INDUSTRY
Responsible Party
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Principal Investigators
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Jeroen van der Grond
Role: PRINCIPAL_INVESTIGATOR
Leiden University Medical Center
Locations
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Leids Universitair Medisch Centrum
Leiden, South Holland, Netherlands
Countries
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References
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van Opstal AM, Hafkemeijer A, van den Berg-Huysmans AA, Hoeksma M, Blonk C, Pijl H, Rombouts SARB, van der Grond J. Brain activity and connectivity changes in response to glucose ingestion. Nutr Neurosci. 2020 Feb;23(2):110-117. doi: 10.1080/1028415X.2018.1477538. Epub 2018 May 27.
Other Identifiers
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1302
Identifier Type: -
Identifier Source: org_study_id
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