Food Reward Processing in the Human Brain

NCT ID: NCT03081585

Last Updated: 2022-03-29

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 23 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-06-09
• Study Completion Date: 2016-06-10

Brief Summary

The aim of this study is to investigate the influence of different metabolic states and hormonal satiety signalling on responses in neural reward networks.

Detailed Description

Given the rapid development of obesity world-wide, a better understanding of the interaction between the encoding of food reward in mesocorticolimbic reward pathways and homeostatic energy regulation is of paramount importance for the development of new treatment strategies. Healthy participants will undergo functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food or monetary reward. Every participant will be scanned twice in a counterbalanced fashion, both during a state of hunger (after 24-hours fasting) and satiety. Blood samples will be collected to assess hormonal satiety signalling. We hope to provide new insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward.

Conditions

Healthy

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Healthy Controls

Normal weight, healthy female participants

Satiety State

Intervention Type: BEHAVIORAL

Participants were scanned twice: once after a meal and once after fasting for 24 hours

Interventions

Satiety State

Participants were scanned twice: once after a meal and once after fasting for 24 hours

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• BMI <25 kg/m² and >18.5 kg/m²
• no lifetime or current medical illness that could potentially affect appetite or body weight
• right-handedness
• normal or corrected-to-normal vision

Exclusion Criteria

• history of head injury or surgery
• history of neurological disorder
• severe psychiatric disorder (psychosis, bipolar disorder, substance abuse)
• smoking
• borderline personality disorder
• current psychotropic medication
• inability to undergo fMRI scanning (e.g. metallic implants, claustrophobia, Pacemakers)
• pregnancy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Heidelberg Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Joe Simon

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Joe Simon, Dr. Dipl. Psych.

Role: PRINCIPAL_INVESTIGATOR

University Hospital Heidelberg

References

Simon JJ, Wetzel A, Sinno MH, Skunde M, Bendszus M, Preissl H, Enck P, Herzog W, Friederich HC. Integration of homeostatic signaling and food reward processing in the human brain. JCI Insight. 2017 Aug 3;2(15):e92970. doi: 10.1172/jci.insight.92970. eCollection 2017 Aug 3.

Reference Type: DERIVED

PMID: 28768906 (View on PubMed)

Other Identifiers

NSM

Identifier Type: -

Identifier Source: org_study_id