The Role of the FTO Gene in Reward System Activation in Obese and Healthy Subjects

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2014-09-30

Brief Summary

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In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant in the FTO gene. From those 500 screened 40 subjects, 20 homozygous for the risk allele and 20 homozygous for a non risk allele will be selected for the second step in the study. This part involves the fMRI technique to visualize the brain response, focus on reward system activation, when food images are visually presented in the scanner. Factors regarding eating behavior, sleep, physical exercise and relation to food are investigated in the first part of the study as well as clinical parameters such as BMI.

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Detailed Description

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Conditions

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Obesity Eating Behavior

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Risk allele carriers

Individuals homozygous for the risk allele (A/A) The interventions administrated to this group: 'Blood sampling for genetic analyse', 'Stroop test', 'fMRI'

Group Type EXPERIMENTAL

Blood sampling for genetic analyse

Intervention Type PROCEDURE

Blood sampling are performed at the initiation visit in order to screen for allele variants

Stroop test

Intervention Type BEHAVIORAL

Selective attention test where subjects, in one minute, names the ink color of several words without naming the word itself.

fMRI

Intervention Type OTHER

Functional Magnetic Resonance Imaging, performed to view brain activity

Non risk allele carriers

Individuals homozygous for the non-risk allele (T/T) The interventions administrated to this group: 'Blood sampling for genetic analyse', 'Stroop test', 'fMRI'

Group Type EXPERIMENTAL

Blood sampling for genetic analyse

Intervention Type PROCEDURE

Blood sampling are performed at the initiation visit in order to screen for allele variants

Stroop test

Intervention Type BEHAVIORAL

Selective attention test where subjects, in one minute, names the ink color of several words without naming the word itself.

fMRI

Intervention Type OTHER

Functional Magnetic Resonance Imaging, performed to view brain activity

Interventions

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Blood sampling for genetic analyse

Blood sampling are performed at the initiation visit in order to screen for allele variants

Intervention Type PROCEDURE

Stroop test

Selective attention test where subjects, in one minute, names the ink color of several words without naming the word itself.

Intervention Type BEHAVIORAL

fMRI

Functional Magnetic Resonance Imaging, performed to view brain activity

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* No medications (except contraceptives including estrogen)
* No metabolic disorders/diseases
* Right handed
* Color vision
* Normal sleep-wake rhythm (eg. shift workers can not participate)