Satiety Effects on the Neural Valuation of Food

NCT ID: NCT01721187

Last Updated: 2015-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2014-07-31

Brief Summary

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Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

Detailed Description

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Conditions

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Fasting Fed

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Low disinhibition

fMRI during fed and fasted states

No interventions assigned to this group

High disinhibition

fMRI during fed and fasted states

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Chinese ethnicity
* 21 to 45 years old
* English as first language
* Right-handed
* Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
* Weigh less than 100kg with an abdominal circumference of less than 120cm
* Non-smoker, or only smoke occasionally (less than 5 sticks a week)
* Consume less than 2 units (200 mg) of caffeine a day
* Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
* Habitually sleep before 1am and wake before 9am

Exclusion Criteria

* On a restrictive diet (e.g., vegetarian/vegan diet)
* History of food allergies
* History of psychiatric or neurological disorders
* History of chronic medical illness
* Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
* Shift worker
* Claustrophobic
* High astigmatism (high = \>2.00 diopters)
* Colour-blind
Minimum Eligible Age

21 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Institute for Human Development and Potential (IHDP), Singapore

OTHER

Sponsor Role collaborator

Duke-NUS Graduate Medical School

OTHER

Sponsor Role lead

Responsible Party

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MChee

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael WL Chee, MBBS

Role: PRINCIPAL_INVESTIGATOR

Duke-NUS Graduate Medical School

Locations

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Centre for Cognitive Neuroscience scanner suite

Singapore, Singapore, Singapore

Site Status

Countries

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Singapore

References

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Plassmann H, O'Doherty J, Rangel A. Orbitofrontal cortex encodes willingness to pay in everyday economic transactions. J Neurosci. 2007 Sep 12;27(37):9984-8. doi: 10.1523/JNEUROSCI.2131-07.2007.

Reference Type BACKGROUND
PMID: 17855612 (View on PubMed)

Knutson B, Westdorp A, Kaiser E, Hommer D. FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage. 2000 Jul;12(1):20-7. doi: 10.1006/nimg.2000.0593.

Reference Type BACKGROUND
PMID: 10875899 (View on PubMed)

Other Identifiers

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VOFIO3G

Identifier Type: -

Identifier Source: org_study_id

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