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An fMRI Study of Satiation in Healthy Volunteers.

NCT ID: NCT02298049

Last Updated: 2014-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-07-31

Study Completion Date

2010-12-31

Brief Summary

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To our knowledge no study has assessed the effects of a meal on neural responses to food cues and compared this with a condition simulating natural inter-meal hunger levels. This is important, as the existing literature often compares the effect of fasting to satiation, which may not reflect typical appetite processes. Thus, the purpose of this research was to examine the effect of a satiating lunch compared to a normal pre-meal state on blood oxygen level dependent (BOLD) activity in the human brain, as measured using functional magnetic resonance imaging (fMRI).

Detailed Description

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We hypothesized that satiation would be associated with decreased brain activity across brain regions involved in both appetite and reward such as ventromedial prefrontal cortex, orbitofrontal cortex, ventral striatum, hypothalamus, insula, amygdala and hippocampus. 16 healthy participants (8 males) were scanned on two separate test days, before and after eating a meal to satiation, or after not eating for 4 hours (satiated vs. pre-meal). fMRI BOLD signals to the sight and/or taste of the stimuli were recorded. Participants were given questionnaires to complete about their mood state and appetite before and after all scans.

Conditions

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Appetite

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Scanning

Repeated measures:

Satiation scan + Pre-meal scan

All participants undertook both scans

Group Type OTHER

Satiated / Pre-meal

Intervention Type OTHER

All participants were scanned before and after not being fed (pre-meal), and before and after being given a satiating lunch (satiated).

MRI

Intervention Type DEVICE

Interventions

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Satiated / Pre-meal

All participants were scanned before and after not being fed (pre-meal), and before and after being given a satiating lunch (satiated).

Intervention Type OTHER

MRI

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers
* Sufficiently fluent in English to understand the task and the instructions

Exclusion Criteria

* Currently taking medication
* Past or current depression/dieting,
* Smokers
* Food allergies
* Diabetes
* Pregnancy
* BMI score outside the normal range
* Any contraindications to fMRI scanning (e.g. pacemakers, mechanical heart valve, hip replacement, metal implants)
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Oxford

OTHER

Sponsor Role collaborator

University of Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jason M Thomas, MRes

Role: PRINCIPAL_INVESTIGATOR

University of Birmingham

Locations

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University of Birmingham

Birmingham, West Midlands, United Kingdom

Site Status

Countries

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United Kingdom

References

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Thomas JM, Higgs S, Dourish CT, Hansen PC, Harmer CJ, McCabe C. Satiation attenuates BOLD activity in brain regions involved in reward and increases activity in dorsolateral prefrontal cortex: an fMRI study in healthy volunteers. Am J Clin Nutr. 2015 Apr;101(4):697-704. doi: 10.3945/ajcn.114.097543. Epub 2015 Jan 21.

Reference Type DERIVED
PMID: 25833968 (View on PubMed)

Other Identifiers

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UBirmingham

Identifier Type: -

Identifier Source: org_study_id