Real-time NIRS Neurofeedback Regulating Brain Cognitive Function in Obese Individuals
NCT ID: NCT04071717
Last Updated: 2019-08-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
90 participants
INTERVENTIONAL
2019-01-01
2020-12-31
Brief Summary
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Detailed Description
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All of the subjects will undergo magnetic resonance imaging scan, during which T1, diffusion tensor imaging, resting-state, and task fMRI data will be collected. For task Fmri scan, the participants will be asked to finish four cognitive task, including 2-Back working memory, Go/No-Go task, Willingness to Pay for Food, and Delay Discounting tasks. Clinical measurements including BMI, eating behavior, psychiatric status will be assessed. Those aforementioned examinations will be performed at before the neurofeedback, 6th times and the end of the treatment.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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NIRS group
Participants with obesity, 12 sessions of NIRS feedback
NIRS neurofeedback
Neurofeedback as a treatment for people which can be interpreted as a way to increase behavioral inhibition. A method to assess brain activity is functional near-infrared spectroscopy (NIRS), measuring hemodynamic correlates of neural activity.
Sham NIRS group
Participants with obesity, 12 sessions of sham NIRS feedback
Sham NIRS neurofeedback
Sham NIRS neurofeedback
Healthy control group
Healthy participants, 12 sessions of NIRS feedback
NIRS neurofeedback
Neurofeedback as a treatment for people which can be interpreted as a way to increase behavioral inhibition. A method to assess brain activity is functional near-infrared spectroscopy (NIRS), measuring hemodynamic correlates of neural activity.
Interventions
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NIRS neurofeedback
Neurofeedback as a treatment for people which can be interpreted as a way to increase behavioral inhibition. A method to assess brain activity is functional near-infrared spectroscopy (NIRS), measuring hemodynamic correlates of neural activity.
Sham NIRS neurofeedback
Sham NIRS neurofeedback
Eligibility Criteria
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Inclusion Criteria
2. 18 to 65 years old
3. No severe mental disorders(depression; schizophrenia; bipolar disorder; etc.).
Exclusion Criteria
2. Substance addiction
3. Patients who cannot be treated with fMRI or fNRIS neurofeedback
4. Those who take other weight loss drugs.
18 Years
65 Years
ALL
Yes
Sponsors
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Xidian University
OTHER
Wu Wenjun-1
OTHER
Responsible Party
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Wu Wenjun-1
Clinical physician
Principal Investigators
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Wenjun Wu, Master
Role: STUDY_CHAIR
Xijing Hospital, The Air Force Medical University
Huaning Wang, Doctor
Role: PRINCIPAL_INVESTIGATOR
Xijing Hospital, The Air Force Medical University
Yi Zhang, professor
Role: PRINCIPAL_INVESTIGATOR
Xidian University
Locations
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Department of Psychiatry, Xijing Hospital, The Air Force Medical University
Xi'an, Shaanxi, China
Countries
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Central Contacts
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Facility Contacts
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References
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Samuel I, Mason EE, Renquist KE, Huang YH, Zimmerman MB, Jamal M. Bariatric surgery trends: an 18-year report from the International Bariatric Surgery Registry. Am J Surg. 2006 Nov;192(5):657-62. doi: 10.1016/j.amjsurg.2006.07.006.
Watanabe T, Sasaki Y, Shibata K, Kawato M. Advances in fMRI Real-Time Neurofeedback: (Trends in Cognitive Sciences 21, 997-1010, 2017). Trends Cogn Sci. 2018 Aug;22(8):738. doi: 10.1016/j.tics.2018.05.007. Epub 2018 Jun 1. No abstract available.
Schwartz DH, Leonard G, Perron M, Richer L, Syme C, Veillette S, Pausova Z, Paus T. Visceral fat is associated with lower executive functioning in adolescents. Int J Obes (Lond). 2013 Oct;37(10):1336-43. doi: 10.1038/ijo.2013.104. Epub 2013 Jun 5.
Diamantis T, Apostolou KG, Alexandrou A, Griniatsos J, Felekouras E, Tsigris C. Review of long-term weight loss results after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2014 Jan-Feb;10(1):177-83. doi: 10.1016/j.soard.2013.11.007. Epub 2013 Nov 21.
Other Identifiers
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KY20192043-F-1
Identifier Type: -
Identifier Source: org_study_id
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