Brain Network Characteristics in Patients With Disorders of Consciousness

NCT ID: NCT05558670

Last Updated: 2022-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-30

Study Completion Date

2023-10-31

Brief Summary

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Simultaneous measurement of the three modalities, functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and electroencephalography (EEG) was proven to be feasible and advantageous in evaluating brain structural and functional (via fMRI), metabolic (via PET) and electrophysiological (via EEG) signatures simultaneously under the same conditions. Investigators use trimodal PET-fMRI-EEG imaging to explore the characteristics of brain network damage in patients with disorders of consciousness(DOC), assess the trajectory of consciousness recovery in a prospective observational cohort study.

Detailed Description

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Conditions

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Disorders of Consciousness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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coma

PET-fMRI-EEG

Intervention Type OTHER

Participants perform PET, fMRI, and EEG simultaneously using a MRI compatible EEG cap

VS/UWS

PET-fMRI-EEG

Intervention Type OTHER

Participants perform PET, fMRI, and EEG simultaneously using a MRI compatible EEG cap

MCS

PET-fMRI-EEG

Intervention Type OTHER

Participants perform PET, fMRI, and EEG simultaneously using a MRI compatible EEG cap

EMCS

PET-fMRI-EEG

Intervention Type OTHER

Participants perform PET, fMRI, and EEG simultaneously using a MRI compatible EEG cap

Interventions

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PET-fMRI-EEG

Participants perform PET, fMRI, and EEG simultaneously using a MRI compatible EEG cap

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Coma, VS/UWS, MCS and EMCS according to diagnostic criteria
2. Age ≥18 years
3. Written informed consent obtained

Exclusion Criteria

1. Patients with contraindications to PET, MRI, EEG examinations or inability to complete PET-fMRI-EEG examinations (presence of ferromagnetic metal implants or hyperthermia)
2. Hyperglycemia that is difficult to correct
3. Patients with long-term use of corticosteroids
4. Patients with coexisting severe systemic disease and limited life expectancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xijing Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wen Jiang

Role: STUDY_DIRECTOR

Xijing Hospital

Locations

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Xijing hospital

Xi'an, Shaanxi, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Rong Chen

Role: CONTACT

18292575563

Facility Contacts

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Rong Chen

Role: primary

18292575563

Other Identifiers

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20222068

Identifier Type: -

Identifier Source: org_study_id

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