Neural and Cognitive Mechanisms of Depression and Anxiety: a Multimodal MRI Study

NCT ID: NCT02888509

Last Updated: 2016-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2017-01-31

Brief Summary

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To explore the neural and cognitive mechanisms of depression (including unipolar depression and Bipolar disorder) and anxiety using multimodal MRI techniques.

Detailed Description

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Conditions

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Depression

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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healthy control

Well mathed with patients in age, gender, education

No interventions assigned to this group

major depression disorder

patients with major depression disorder

No interventions assigned to this group

anxiety disorder

patients with anxiety disorder

No interventions assigned to this group

bipolar depression disorder

patients with bilopar depression disorder

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age range from 16 to 55 years old.
* All patients were interviewed by two experienced psychiatrists using the Structured Clinical Interview for DSM-IV (patient edition)

Exclusion Criteria

* Schizophrenia, mental retardation or personality disorder, any history of loss of consciousness, substance abuse, serious medical or neurological illness.
* Subjects with contraindications to MRI
Minimum Eligible Age

16 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Electronic Science and Technology of China

OTHER

Sponsor Role lead

Responsible Party

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chenhuafu

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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School of Life Science and Technology, University of Electronic Science and Technology

Chengdu, Sichuan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Huafu Chen

Role: CONTACT

Facility Contacts

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Huafu Chen

Role: primary

References

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Chen Y, Cui Q, Sheng W, Tang Q, Lu F, Pang Y, Nan X, He Z, Li D, Lei T, Chen H. Anomalous neurovascular coupling in patients with generalized anxiety disorder evaluated by combining cerebral blood flow and functional connectivity strength. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110379. doi: 10.1016/j.pnpbp.2021.110379. Epub 2021 Jun 7.

Reference Type DERIVED
PMID: 34111495 (View on PubMed)

Yang Y, Cui Q, Pang Y, Chen Y, Tang Q, Guo X, Han S, Ameen Fateh A, Lu F, He Z, Huang J, Xie A, Li D, Lei T, Wang Y, Chen H. Frequency-specific alteration of functional connectivity density in bipolar disorder depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110026. doi: 10.1016/j.pnpbp.2020.110026. Epub 2020 Jul 2.

Reference Type DERIVED
PMID: 32621959 (View on PubMed)

Wang Y, Wang X, Ye L, Yang Q, Cui Q, He Z, Li L, Yang X, Zou Q, Yang P, Liu D, Chen H. Spatial complexity of brain signal is altered in patients with generalized anxiety disorder. J Affect Disord. 2019 Mar 1;246:387-393. doi: 10.1016/j.jad.2018.12.107. Epub 2018 Dec 26.

Reference Type DERIVED
PMID: 30597300 (View on PubMed)

Other Identifiers

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UESTC-chenhuafulab-002

Identifier Type: -

Identifier Source: org_study_id

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