Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

77 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-05-31

Study Completion Date

2015-07-31

Brief Summary

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To examine whether the medial prefrontal cortex displays an increased activity during self-referential processing among remitted depressed patients compared to healthy controls

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Detailed Description

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Conditions

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Major Depression

Study Design

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Observational Model Type

CASE_CONTROL

Study Groups

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Remitted depressed patients

Formerly depressed patients in remission for 6 months or more

No interventions assigned to this group

healthy controls

healthy subjects with no history of mental disorders

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* History of at least one major depressive episode
* In clinical remission for at least 6 months (BDI-21 ≤ 10 \& Montgomery and Asberg Depression Rating Scale ≤ 7)
* Aged 20-65

Exclusion Criteria

* first depressive episode after the age of 59
* last episode treated by cognitive behavior therapy
* currently receiving a antipsychotic or mood-stabilizing drug
* personal history of: major depressive episode with psychotic features, other axis-I disorder (except generalized anxiety disorder), substance-related disorder (except nicotine dependence), bipolar disorder
* first-degree familial history of bipolar disorder
* cognitive impairment due to another central nervous system disease
* contra-indication to MRI
* pregnancy
* refusal to be informed of abnormal findings during the MRI

Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes