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How do Patients With Amnesia Acquire New Knowledge?

NCT ID: NCT07191197

Last Updated: 2025-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-01

Study Completion Date

2030-01-31

Brief Summary

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THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.

Detailed Description

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The preservation of learning abilities is an essential aspect in the implementation of cognitive rehabilitation programs for patients with an amnesic syndrome. Particularly disabled on a daily basis, these patients have significant difficulties in coping with the demands of work and family life. Data from previous case studies attest to the ability of these patients to rely on preserved cognitive systems to learn new semantic information. However, the procedures for the acquisition of new information are sometimes long, not optimal and the clinical factors, that can influence it, are poorly identified. In addition, the brain networks necessary for such learning are still debated. In order to better understand the cognitive mechanisms and brain networks that underlie the ability to learn new semantic information, the research aims to study a group of patients with major memory impairment following medial temporal lobe lesions of various etiologies (non-degenerative). The study will use a combined psychometric and neuroimaging approach to identify the factors that enable these patients to successfully learn new semantic information.

Conditions

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Amnesia Memory Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

sectional, experimental, comparative, bicentric study.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Learning abilities for Patients with an amnesic syndrome

1 MRI session, 2 cognitive research tasks of semantic learning, and neuropsychological assessment.

Group Type EXPERIMENTAL

MRI

Intervention Type OTHER

structural and functional resting state MRI

Psychometric

Intervention Type OTHER

2 cognitive research tasks of semantic learning and neuropsychological assessment

Healthy controls

To allow multiple pairing for each patient, a group of 120 healthy controls aged between 18 to 70 years old will be recruited. Thus, it will be possible to compare one given patient to a group of 40 aged-matched subjects.

All healthy volunteers will undergo the same intervention as the patients :

1 MRI session, 2 cognitive research tasks of semantic learning, neuropsychological assessment.

Group Type ACTIVE_COMPARATOR

MRI

Intervention Type OTHER

structural and functional resting state MRI

Psychometric

Intervention Type OTHER

2 cognitive research tasks of semantic learning and neuropsychological assessment

Interventions

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MRI

structural and functional resting state MRI

Intervention Type OTHER

Psychometric

2 cognitive research tasks of semantic learning and neuropsychological assessment

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients aged between 18 and 70 years
* Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation
* Written agreement to participate in the study
* Intellectual capacities compatible with the cognitive tasks and signing of consent
* Affiliation to the French social security system
* For patients: bilateral brain lesion of the medial temporal lobe or the extended hippocampal system

Exclusion Criteria

* Subjects under the age of 18 or over 70
* Contraindications for MRI (examples: wearers of a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, wearers of haemostatic clips for intracerebral aneurysms or carotid arteries, wearers of orthopedic implants, claustrophobic)
* Refusal to be informed of an anomaly detected during the MRI
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Research Agency, France

OTHER

Sponsor Role collaborator

University Hospital, Toulouse

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Hospital of Caen

Caen, , France

Site Status

University Hospital of Toulouse

Toulouse, , France

Site Status

Countries

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France

Central Contacts

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Jérémie PARIENTE, MD + PHD

Role: CONTACT

[email protected]
05 61 77 94 88

Facility Contacts

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Olivier MARTINAUD, MD + PHD

Role: primary

[email protected]
33 + 0231064617

Jérémie PARIENTE, MD + PHD

Role: primary

[email protected]
05 61 77 94 88

Clémence Le Bervet, MASTER

Role: backup

[email protected]
0561777087

Other Identifiers

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RC31/23/0377

Identifier Type: -

Identifier Source: org_study_id