Effect of Sweetness Intensity of a Sucrose Solution on Blood Glucose Regulation and Energy Intake

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-05

Study Completion Date

2022-12-30

Brief Summary

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The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger \& satiety.

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Detailed Description

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The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.

Conditions

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Blood Glucose, Low Hunger

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Sucrose

10% solution in water

Group Type EXPERIMENTAL

Sucrose

Intervention Type OTHER

10% Sucrose corresponding to a regular soft drink

Sucrose + Reb M

10% sucrose + 60 mg/L Rebaudioside M

Group Type EXPERIMENTAL

Rebaudioside M

Intervention Type DRUG

Sweetener (increases sweetness)

Sucrose

Intervention Type OTHER

10% Sucrose corresponding to a regular soft drink

Sucrose + Lactisole

10% sucrose + 30 mg/ L Lactisole

Group Type EXPERIMENTAL

Lactisole

Intervention Type DRUG

sweet taste inhibitor (decreases sweetness)

Sucrose

Intervention Type OTHER

10% Sucrose corresponding to a regular soft drink

Sucrose + Reb M + Lactisole

10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole

Group Type EXPERIMENTAL

Lactisole

Intervention Type DRUG

sweet taste inhibitor (decreases sweetness)

Rebaudioside M

Intervention Type DRUG

Sweetener (increases sweetness)

Sucrose

Intervention Type OTHER

10% Sucrose corresponding to a regular soft drink

Interventions

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Lactisole

sweet taste inhibitor (decreases sweetness)

Intervention Type DRUG

Rebaudioside M

Sweetener (increases sweetness)

Intervention Type DRUG

Sucrose

10% Sucrose corresponding to a regular soft drink

Intervention Type OTHER

Other Intervention Names

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2-(4-methoxyphenoxy)propionic acid CAS Number: 150436-68-3 CAS Number: 1220616-44-3 table sugar

Eligibility Criteria

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Inclusion Criteria

* male
* healthy
* non-smoking
* normal taste responses towards sweet taste

Exclusion Criteria

* female
* regular smokers
* disturbed glucose and/or lipid metabolism
* regular intake of medication
* known allergies against one of the test compounds
* ageusia
* alcohol or drug addiction
* intake of antibiotics within the past 2 months

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes