Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
EARLY_PHASE1
65 participants
INTERVENTIONAL
2023-01-16
2026-12-14
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Evaluating motor learning and brain structures post-stroke
We will use a single arm design to determine the impact of post-stroke cognitive impairment on two forms of motor learning (implicit and explicit) and evaluate the structural integrity of relevant brain structures in 65 individuals post stroke
Explicit motor learning
Participants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.
Implicit motor learning
Participants will walk on a treadmill that drives their right and left legs to move at two different speeds.
Interventions
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Explicit motor learning
Participants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.
Implicit motor learning
Participants will walk on a treadmill that drives their right and left legs to move at two different speeds.
Eligibility Criteria
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Inclusion Criteria
* Stroke occurred more than 6 months prior
* Paresis confined to one side
* Independently ambulatory (including the use of assistive devices)
* Able to walk for 5 minutes without stopping
* Answers no to all general health questions on the PAR-Q+
* Willingness to complete study procedures
Exclusion Criteria
* Aphasia (expressive, receptive, or global)
* Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
* Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
* Uncontrolled hypertension (\>160/110mmHg)
* Concurrent physical therapy
* Claustrophobia
* Significant cognitive deficit or dementia (\<20 on MoCA)
* Inability to give informed consent
45 Years
85 Years
ALL
No
Sponsors
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University of Southern California
OTHER
Responsible Party
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Kristan Leech
Principal Investigator
Principal Investigators
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Kristan Leech, PT, DPT, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Southern California
Locations
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Center for Health Professions
Los Angeles, California, United States
Countries
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Central Contacts
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Facility Contacts
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Kristan Leech, PT, DPT, PhD
Role: primary
Other Identifiers
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APP-21-00898
Identifier Type: -
Identifier Source: org_study_id
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