Post Stroke Motor Learning

NCT ID: NCT01519843

Last Updated: 2023-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2030-12-31

Brief Summary

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Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.

Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.

Detailed Description

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transcranial direct current stimulation will be used for NIBS

Conditions

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Stroke Hemiparesis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Real

Real tDCS

Group Type ACTIVE_COMPARATOR

transcranial direct current stimulation tDCS

Intervention Type DEVICE

tdcs (ELDITH, Neuroconn, Ilmenau, Germany)

transcranial magnetic stimulation TMS

Intervention Type DEVICE

TMS (The Magstim Company Ltd, UK) Magstim 200² with a figure-of-eight coil was used to determine the hot spot eliciting consistent movements in the contralateral hand

sham

Sham tDCS

Group Type PLACEBO_COMPARATOR

transcranial direct current stimulation tDCS

Intervention Type DEVICE

tdcs (ELDITH, Neuroconn, Ilmenau, Germany)

transcranial magnetic stimulation TMS

Intervention Type DEVICE

TMS (The Magstim Company Ltd, UK) Magstim 200² with a figure-of-eight coil was used to determine the hot spot eliciting consistent movements in the contralateral hand

Interventions

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transcranial direct current stimulation tDCS

tdcs (ELDITH, Neuroconn, Ilmenau, Germany)

Intervention Type DEVICE

transcranial magnetic stimulation TMS

TMS (The Magstim Company Ltd, UK) Magstim 200² with a figure-of-eight coil was used to determine the hot spot eliciting consistent movements in the contralateral hand

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* stroke with at least slight deficit

Exclusion Criteria

* epilepsy
* contraindication to tDCS and/or to fMRI
* presence of metal in the head
* inability to understand / complete behavioral tasks
* chronic intake of alcohol or recreational drugs
* major health condition
* presence of pacemaker (for the fMRI part only)
* pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital of Mont-Godinne

OTHER

Sponsor Role lead

Responsible Party

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Pr Yves Vandermeeren, MD, PhD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Neurology, CHU Mont-Godinne

Yvoir, Namur, Belgium

Site Status

Countries

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Belgium

References

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Riga A, Gathy E, Ghinet M, De Laet C, Bihin B, Regnier M, Leeuwerck M, De Coene B, Dricot L, Herman B, Edwards MG, Vandermeeren Y. Evidence of Motor Skill Learning in Acute Stroke Patients Without Lesions to the Thalamus and Internal Capsule. Stroke. 2022 Jul;53(7):2361-2368. doi: 10.1161/STROKEAHA.121.035494. Epub 2022 Mar 21.

Reference Type DERIVED
PMID: 35311345 (View on PubMed)

Elsner B, Kugler J, Pohl M, Mehrholz J. Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke. Cochrane Database Syst Rev. 2020 Nov 11;11(11):CD009645. doi: 10.1002/14651858.CD009645.pub4.

Reference Type DERIVED
PMID: 33175411 (View on PubMed)

Other Identifiers

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B039201212957

Identifier Type: -

Identifier Source: org_study_id

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