Resuscitation and Capillary Reperfusion

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-03

Study Completion Date

2022-05-01

Brief Summary

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Persistent microperfusion alterations after return of spontaneous circulation (ROSC) are associated with poor survival. To our knowledge, no human studies evaluating microperfusion during cardiopulmonary resuscitation (CPR) with simple and pre-hospital available tests have been published. Capillary refill time (CRT) and skin-mottling-score (SMS) are parameters for microperfusion and evaluated in septic and cardiogenic shock. In animal studies, microperfusion was impaired during cardiac arrest, although not correlating with systemic blood pressure.

The aim of this study is to investigate the correlation between impaired microcirculation (as measured with CRT and SMS) during resuscitation and ROSC resp. neurological outcome. Our clinical impression in daily routine is, that the appearance of a patient undergoing CPR is often linked to the outcome. We hypothesize, that this is due to changes in microperfusion of the skin.

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Detailed Description

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Conditions

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Cardiac Arrest Cardiac Arrest, Out-Of-Hospital Cardiopulmonary Arrest Cardiopulmonary Arrest With Successful Resuscitation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* All patients ≥18 years during cardiopulmonary resuscitation
* witnessed cardiac arrest

Exclusion Criteria

* insufficient manpower (e.g. study team has to provide CPR)
* hypovolemia (exsanguination, anaphylaxis, sepsis as underlying cause)
* presumed or known COVID-19 disease
* hypo-/hyperthermia (\<36.0°, \>37.5°C)
* Raynaud's disease
* Peripheral arterial disease

Minimum Eligible Age

18 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No