Correlation Between End-tidal CO2 and Degree of Compression of Heart During CPR Measured by Ultrasound

NCT ID: NCT03852225

Last Updated: 2019-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2019-03-31

Brief Summary

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Individual optimization of cardiopulmonary resuscitation (CPR) in real time may increase the success rate of the procedure. End-tidal CO2 (EtCO2) levels reflect cardiac output induced by CPR. Other potential marker of haemodynamic efficacy of CPR is direct measurement of the extent of induced compression of left ventricle (LV), right ventricle (RV) and inferior caval vein (IVC) by ultrasound. We plane to evaluate whether these ultrasound parameters correlate with EtCO2 levels during CPR for out-of-hospital cardiac arrest (OHCA) of non-traumatic origin.

Detailed Description

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Pre-hospital observational study will be realized in the setting of physician-based Emergency Medical System in the Czech republic. 20 patients resuscitated for OHCA of nontraumatic origin are planned to be included to the study. Transthoracic echocardiography will be performed from subcostal view during ongoing chest compressions in all of them and in the time of this investigation EtCO2 level will be recorded. This will be repeated three times during CPR in each patient if possible. Later on, maximal and minimal diameter of LV, RV and IVC will be obtained from the recorded loops and compression index (%) of LV (LVCI), RV (RVCI) and IVC (IVCCI) will be calculated as (maximal-minimal/maximal cavital diameter)x100. Correlations between EtCO2 and LVCI, RVCI and IVCI and CImax will be expressed as Spearman's correlation coefficient.

The results of the study will answer the question whether echocardiographic evaluation of compression of heart cavities during CPR reflect haemodynamic efficacy of CPR. If so, this study will be followed by an interventional clinical trial evaluating the effect of compression depth changes as a response to measured compression of the heart.

Conditions

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Cardiopulmonary Resuscitation Echocardiography

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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OHCA patients

Patients resuscitated for out-of-hospital cardiac arrest of non-traumatic origin and investigated by intra-arrest echocardiography.

Intra-arrest echocardiography

Intervention Type DIAGNOSTIC_TEST

Intra-arrest echocardiography performed by portable ultrasound device during ongoing chest compressions.

Interventions

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Intra-arrest echocardiography

Intra-arrest echocardiography performed by portable ultrasound device during ongoing chest compressions.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Adult patient resuscitated for out-of-hospital cardiac arrest of non-traumatic origin.

Exclusion Criteria

* Technical unavailability of intra-arrest ultrasonography and capnography.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Masaryk Hospital Usti nad Labem

OTHER

Sponsor Role collaborator

Emergency Medical Service of the Central Bohemian Region, Czech Republic

OTHER

Sponsor Role lead

Responsible Party

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Roman Skulec

Roman Skulec, MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Emergency Medical Service of the Central Bohemian Region

Kladno, Central Bohemia, Czechia

Site Status RECRUITING

Countries

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Czechia

Facility Contacts

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Roman Skulec, MD

Role: primary

00420 777 577 497

Jitka Callerova, MD

Role: backup

00420 777 844 471

References

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Skulec R, Vojtisek P, Cerny V. Correlation between end-tidal carbon dioxide and the degree of compression of heart cavities measured by transthoracic echocardiography during cardiopulmonary resuscitation for out-of-hospital cardiac arrest. Crit Care. 2019 Oct 29;23(1):334. doi: 10.1186/s13054-019-2607-2.

Reference Type DERIVED
PMID: 31665061 (View on PubMed)

Other Identifiers

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2018-02

Identifier Type: -

Identifier Source: org_study_id

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