Adjusting CPR Location With TEE Guidance

NCT ID: NCT07017075

Last Updated: 2025-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-02-21

Study Completion Date

2027-01-21

Brief Summary

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Use Transesophageal ultrasound in OHCA patients to identify the proper compression location

Detailed Description

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For patients with cardiac arrest, high-quality cardiopulmonary resuscitation is performed according to critical care management and Advanced Cardiac Life Support (ACLS). Rapid with powerful chest compression should be performed to maintain the heart's output and blood flow. An advanced airway should be established and adjust resuscitation based on collected clinical information. Transesophageal ultrasound examination is performed after the advanced airway is established without affecting the resuscitation. The investigators use the built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)) to analyze stroke volume and cardiac output. The investigators collect the stroke volume and cardiac output at the chest compression position recommended by ACLS, as well as the stroke volume and cardiac output after adjusting the optimal chest compression position. The investigators expect it can increase the return of spontaneous circulation rate, survival rate, and neurological prognosis over time.

Conditions

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Cardiac Arrest (CA)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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CPR location without adjustment

If the AMC was located at the LV identified by TEE, the CPR compression site was not altered.

Group Type OTHER

adjustment of CPR location

Intervention Type BEHAVIORAL

Transesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in traditional CPR location and the better position

CPR location with adjustment

If the AMC was not located at the LV, the CPR compression site was altered.

Group Type OTHER

adjustment of CPR location

Intervention Type BEHAVIORAL

Transesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in traditional CPR location and the better position

Interventions

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adjustment of CPR location

Transesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in traditional CPR location and the better position

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Out-of-hospital cardiac arrest patients

Exclusion Criteria

* DNR was signed
* Age under 18
* Trauma patients
* Patients hard to establish an advanced airway
* Inavailability of ultrasound machine or operators
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Bing Show Chwan Memorial Hospital

OTHER

Sponsor Role collaborator

National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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WANCHING LIEN

Role: STUDY_DIRECTOR

National Taiwan University Hospital

Locations

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Chang Bing Show Chawan Memorial Hospital

Changhua, , Taiwan

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Countries

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Taiwan

References

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Chen CC, Huang CS, Yen HT, Lien WC. A visualization of ejection fraction change after adjusting the area of maximal compression. Resuscitation. 2024 Jan;194:110097. doi: 10.1016/j.resuscitation.2023.110097. Epub 2023 Dec 20. No abstract available.

Reference Type RESULT
PMID: 38128870 (View on PubMed)

Teran F, Owyang CG, Martin-Flores M, Lao D, King A, Palasz J, Araos JD. Hemodynamic impact of chest compression location during cardiopulmonary resuscitation guided by transesophageal echocardiography. Crit Care. 2023 Aug 19;27(1):319. doi: 10.1186/s13054-023-04575-7. No abstract available.

Reference Type RESULT
PMID: 37598201 (View on PubMed)

Hwang SO, Zhao PG, Choi HJ, Park KH, Cha KC, Park SM, Kim SC, Kim H, Lee KH. Compression of the left ventricular outflow tract during cardiopulmonary resuscitation. Acad Emerg Med. 2009 Oct;16(10):928-33. doi: 10.1111/j.1553-2712.2009.00497.x. Epub 2009 Sep 3.

Reference Type RESULT
PMID: 19732038 (View on PubMed)

Olasveengen TM, Semeraro F, Ristagno G, Castren M, Handley A, Kuzovlev A, Monsieurs KG, Raffay V, Smyth M, Soar J, Svavarsdottir H, Perkins GD. European Resuscitation Council Guidelines 2021: Basic Life Support. Resuscitation. 2021 Apr;161:98-114. doi: 10.1016/j.resuscitation.2021.02.009. Epub 2021 Mar 24.

Reference Type RESULT
PMID: 33773835 (View on PubMed)

Other Identifiers

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202410013RINB

Identifier Type: -

Identifier Source: org_study_id

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